MRP-L39 Antibody (F-10): sc-271743
- MRP-L39 Antibody (F-10) is a mouse monoclonal IgG2a κ MRP-L39 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 179-213 within an internal region of MRP-L39 of human origin
- MRP-L39 Antibody (F-10) is recommended for detection of MRP-L39 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including bovine
- Anti-MRP-L39 Antibody (F-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MRP-L39 Antibody (F-10) for WB and IHC(P) applications. These reagents are now offered in bundles with MRP-L39 Antibody (F-10) (see ordering information below).
MRP-L39 Antibody (F-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects MRP-L39 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MRP-L39 (F-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MRP-L39, also known as mitochondrial ribosomal protein L39, MRP-L5, L39mt, or L5mt, is a crucial component of the mitochondrial ribosomal 39S subunit, which plays a vital role in mitochondrial protein synthesis. This 338 amino acid protein is essential for proper mitochondrial functioning, collaborating with other mitochondrial ribosomal proteins to facilitate mitochondrial mRNA translation into functional proteins. MRP-L39 exists in two isoforms due to alternative splicing, with one isoform being ubiquitously expressed and another specifically found in heart tissue, highlighting potential significance in cardiac function. The gene encoding MRP-L39 is located on chromosome 21, notable for association with various diseases, including Down syndrome, Alzheimer′s disease, and amyotrophic lateral sclerosis. Anti-MRP-L39 antibody (F-10) effectively detects this protein across multiple species and applications, making MRP-L39 (F-10) monoclonal antibody an invaluable tool for researchers studying mitochondrial function and related pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MRP-L39 Antibody (F-10) References:
- Molecular cytogenetic dissection of human chromosomes 3 and 21 evolution. | Müller, S., et al. 2000. Proc Natl Acad Sci U S A. 97: 206-11. PMID: 10618396
- Heart-specific splice-variant of a human mitochondrial ribosomal protein (mRNA processing; tissue specific splicing). | Spirina, O., et al. 2000. Gene. 261: 229-34. PMID: 11167009
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. | Kenmochi, N., et al. 2001. Genomics. 77: 65-70. PMID: 11543634
- Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease. | O'Brien, TW. 2002. Gene. 286: 73-9. PMID: 11943462
- Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. | Zhang, Z. and Gerstein, M. 2003. Genomics. 81: 468-80. PMID: 12706105
- BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome. | Sun, X., et al. 2006. FASEB J. 20: 1369-76. PMID: 16816112
- The discovery and mapping to chromosome 21 of the Alzheimer's amyloid gene: history revised. | Robakis, NK. 2006. J Alzheimers Dis. 10: 453-5. PMID: 17183160
- Classification of human chromosome 21 gene-expression variations in Down syndrome: impact on disease phenotypes. | Aït Yahya-Graison, E., et al. 2007. Am J Hum Genet. 81: 475-91. PMID: 17701894
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRP-L39 Antibody (F-10) | sc-271743 | 200 µg/ml | $322.00 | |||
MRP-L39 Antibody (F-10): m-IgGκ BP-HRP Bundle | sc-522047 | 200 µg Ab, 40 µg BP | $361.00 | |||
MRP-L39 Antibody (F-10): m-IgG2a BP-HRP Bundle | sc-546106 | 200 µg Ab; 10 µg BP | $361.00 | |||
MRP-L39 Antibody (F-10) AC | sc-271743 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MRP-L39 Antibody (F-10) HRP | sc-271743 HRP | 200 µg/ml | $322.00 | |||
MRP-L39 Antibody (F-10) FITC | sc-271743 FITC | 200 µg/ml | $336.00 | |||
MRP-L39 Antibody (F-10) PE | sc-271743 PE | 200 µg/ml | $349.00 | |||
MRP-L39 Antibody (F-10) Alexa Fluor® 488 | sc-271743 AF488 | 200 µg/ml | $364.00 | |||
MRP-L39 Antibody (F-10) Alexa Fluor® 546 | sc-271743 AF546 | 200 µg/ml | $364.00 | |||
MRP-L39 Antibody (F-10) Alexa Fluor® 594 | sc-271743 AF594 | 200 µg/ml | $364.00 | |||
MRP-L39 Antibody (F-10) Alexa Fluor® 647 | sc-271743 AF647 | 200 µg/ml | $364.00 | |||
MRP-L39 Antibody (F-10) Alexa Fluor® 680 | sc-271743 AF680 | 200 µg/ml | $364.00 | |||
MRP-L39 Antibody (F-10) Alexa Fluor® 790 | sc-271743 AF790 | 200 µg/ml | $364.00 | |||
MRP-L39 (F-10) Neutralizing Peptide | sc-271743 P | 100 µg/0.5 ml | $69.00 |