mPRδ/γ Antibody (B-8): sc-514273

mPRδ/γ Antibody (B-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects mPR delta / gamma protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). mPR delta / gamma (B-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. mPR delta / gamma protein plays a crucial role in mediating progesterone′s effects, which is essential for various reproductive processes, including oocyte maturation resumption. mPR delta / gamma protein operates through a nongenomic signaling pathway, binding to progesterone and subsequently inhibiting adenylyl cyclase, leading to decreased intracellular cyclic adenosine monophosphate levels. mPR delta / gamma protein also activates mitogen-activated protein kinase, vital for signal transduction influencing cellular responses. mPR delta / gamma protein belongs to a larger membrane progestin receptor family including five distinct groups—α, β, γ, δ, and ε—each with unique tissue distributions in reproductive, neural, kidney, and intestinal systems. These characteristics distinguish membrane progestin receptors from traditional nuclear progestin receptors and suggest functional similarity to G-protein coupled receptors, highlighting their significance in reproductive biology and as potential therapeutic targets.

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mPRδ/γ Antibody (B-8) References:

1. Regulation of Xenopus oocyte meiosis arrest by G protein betagamma subunits.  |  Sheng, Y., et al. 2001. Curr Biol. 11: 405-16. PMID: 11301251
2. Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes.  |  Zhu, Y., et al. 2003. Proc Natl Acad Sci U S A. 100: 2231-6. PMID: 12574519
3. Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor.  |  Zhu, Y., et al. 2003. Proc Natl Acad Sci U S A. 100: 2237-42. PMID: 12601167
4. The distribution of progestin receptor mRNA in rat brainstem.  |  Curran-Rauhut, MA. and Petersen, SL. 2002. Brain Res Gene Expr Patterns. 1: 151-7. PMID: 12638125
5. Double oestrogen receptor alpha and beta knockout mice reveal differences in neural oestrogen-mediated progestin receptor induction and female sexual behaviour.  |  Kudwa, AE. and Rissman, EF. 2003. J Neuroendocrinol. 15: 978-83. PMID: 12969243
6. Immunocytochemical investigation of nuclear progestin receptor expression within dopaminergic neurones of the female rat brain.  |  Lonstein, JS. and Blaustein, JD. 2004. J Neuroendocrinol. 16: 534-43. PMID: 15189328
7. Estrogen receptor beta modulates estradiol induction of progestin receptor immunoreactivity in male, but not in female, mouse medial preoptic area.  |  Kudwa, AE., et al. 2004. Endocrinology. 145: 4500-6. PMID: 15205372
8. Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors.  |  Smith, JL., et al. 2008. Steroids. 73: 1160-73. PMID: 18603275
9. Sebaceous gland receptors.  |  Zouboulis, CC. 2009. Dermatoendocrinol. 1: 77-80. PMID: 20224688
10. Characterization, neurosteroid binding and brain distribution of human membrane progesterone receptors δ and {epsilon} (mPRδ and mPR{epsilon}) and mPRδ involvement in neurosteroid inhibition of apoptosis.  |  Pang, Y., et al. 2013. Endocrinology. 154: 283-95. PMID: 23161870
11. Anti-apoptotic Actions of Allopregnanolone and Ganaxolone Mediated Through Membrane Progesterone Receptors (PAQRs) in Neuronal Cells.  |  Thomas, P. and Pang, Y. 2020. Front Endocrinol (Lausanne). 11: 417. PMID: 32670200
12. Therapeutic targets for endometriosis: Genome-wide Mendelian randomization and colocalization analyses.  |  Zeng, P., et al. 2024. Gene. 893: 147970. PMID: 37931855

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-mPRδ/γ Antibody (B-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-mPRδ/γ Antibody (B-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

mPRδ/γ Antibody (B-8) Specifications

Alternate Product Name: mPRδ/γ

Product Clone Name: B-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 234-257

Epitope Target: mPRγ

Epitope Species: human

Product Reactivity/Detection: mPRδ and mPRγ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for mPRδ/γ Antibody (B-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin