MPO/Myeloperoxidase Antibody (4A4): sc-52076

MPO Antibody (4A4) is a mouse monoclonal IgG2b antibody that detects myeloperoxidase (MPO) in human samples through western blotting (WB) and immunoprecipitation (IP) applications. Anti-MPO antibody (4A4) plays a crucial role in understanding the function of MPO, a heme protein that is essential for the oxygen-dependent microbiocidal activity of neutrophils and polymorphonuclear leukocytes. This enzyme catalyzes the production of hypochlorous acid and other reactive oxygen species, which are vital for the immune response against pathogens. The proper functioning of MPO is critical, as deficiencies or dysfunctions in this enzyme can lead to increased susceptibility to infections and inflammatory diseases. MPO is synthesized as a precursor during the promyelocytic stage of myeloid differentiation and undergoes a series of post-translational modifications, including cotranslational N-linked glycosylation, which is essential for its maturation and function. The fully glycosylated form of MPO is transported to lysosomes, where MPO is processed into its active dimeric form, allowing MPO to exert its microbiocidal effects. MPO (4A4) antibody is particularly valuable for researchers studying the immune response and the role of neutrophils in various diseases, as MPO (4A4) antibody provides a reliable means to detect and analyze MPO expression in human samples.

The preferred MPO/Myeloperoxidase antibody is MPO/Myeloperoxidase Antibody (266-6K1): sc-52707.