MPHOSPH8 Antibody (C-8): sc-398598
- MPHOSPH8 Antibody (C-8) is a mouse monoclonal IgG1 κ MPHOSPH8 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 465-660 mapping within an internal region of MPHOSPH8 of human origin
- MPHOSPH8 Antibody (C-8) is recommended for detection of MPHOSPH8 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MPHOSPH8 Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MPHOSPH8 Antibody (C-8) for WB applications. These reagents are now offered in bundles with MPHOSPH8 Antibody (C-8) (see ordering information below).
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MPHOSPH8 Antibody (C-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects MPHOSPH8 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MPHOSPH8 antibody (C-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MPHOSPH8, also known as M-phase phosphoprotein 8, is an 860 amino acid nuclear protein that plays a critical role during the M (mitotic) phase of the cell cycle, where MPHOSPH8 undergoes phosphorylation. This post-translational modification is essential for regulating MPHOSPH8′s function, as MPHOSPH8 is involved in the orchestration of cell division and may influence the activity of various cell cycle regulators. MPHOSPH8 contains four ankyrin repeats, which are structural motifs commonly associated with protein-protein interactions, suggesting MPHOSPH8′s potential role in forming complexes with other proteins, such as Muskelin and RanBP-M, a GTPase that is crucial for numerous cellular processes. The gene encoding MPHOSPH8 is located on chromosome 13 and gives rise to two isoforms through alternative splicing, highlighting the complexity and regulatory mechanisms governing MPHOSPH8′s expression and function in cellular dynamics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MPHOSPH8 Antibody (C-8) References:
- A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM. | Umeda, M., et al. 2003. Gene. 303: 47-54. PMID: 12559565
- RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex. | Kobayashi, N., et al. 2007. Gene. 396: 236-47. PMID: 17467196
- [Functional role of proteins containing ankyrin repeats]. | Voronin, DA. and Kiseleva, EV. 2007. Tsitologiia. 49: 989-99. PMID: 18318217
- A primer on ankyrin repeat function in TRP channels and beyond. | Gaudet, R. 2008. Mol Biosyst. 4: 372-9. PMID: 18414734
- Novel role of the muskelin-RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation. | Valiyaveettil, M., et al. 2008. J Cell Biol. 182: 727-39. PMID: 18710924
- RanBPM regulates cell shape, arrangement, and capacity of the female germline stem cell niche in Drosophila melanogaster. | Dansereau, DA. and Lasko, P. 2008. J Cell Biol. 182: 963-77. PMID: 18762575
- Identification of novel M phase phosphoproteins by expression cloning. | Matsumoto-Taniura, N., et al. 1996. Mol Biol Cell. 7: 1455-69. PMID: 8885239
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MPHOSPH8 Antibody (C-8) | sc-398598 | 200 µg/ml | $322.00 | |||
MPHOSPH8 Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-530863 | 200 µg Ab; 10 µg BP | $361.00 | |||
MPHOSPH8 Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-524412 | 200 µg Ab, 40 µg BP | $361.00 | |||
MPHOSPH8 Antibody (C-8): m-IgG1 BP-HRP Bundle | sc-544286 | 200 µg Ab; 20 µg BP | $361.00 | |||
MPHOSPH8 Antibody (C-8) AC | sc-398598 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MPHOSPH8 Antibody (C-8) HRP | sc-398598 HRP | 200 µg/ml | $322.00 | |||
MPHOSPH8 Antibody (C-8) FITC | sc-398598 FITC | 200 µg/ml | $336.00 | |||
MPHOSPH8 Antibody (C-8) PE | sc-398598 PE | 200 µg/ml | $349.00 | |||
MPHOSPH8 Antibody (C-8) Alexa Fluor® 488 | sc-398598 AF488 | 200 µg/ml | $364.00 | |||
MPHOSPH8 Antibody (C-8) Alexa Fluor® 546 | sc-398598 AF546 | 200 µg/ml | $364.00 | |||
MPHOSPH8 Antibody (C-8) Alexa Fluor® 594 | sc-398598 AF594 | 200 µg/ml | $364.00 | |||
MPHOSPH8 Antibody (C-8) Alexa Fluor® 647 | sc-398598 AF647 | 200 µg/ml | $364.00 | |||
MPHOSPH8 Antibody (C-8) Alexa Fluor® 680 | sc-398598 AF680 | 200 µg/ml | $364.00 | |||
MPHOSPH8 Antibody (C-8) Alexa Fluor® 790 | sc-398598 AF790 | 200 µg/ml | $364.00 |