Mox1 Antibody (C-10): sc-518023

Mox1 Antibody (C-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Mox1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Mox1 (C-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Mox1 plays a crucial role in regulating reactive oxygen species, particularly in non-phagocytic cells, and shares close relation to glycoprotein gp91 phox, a key component of NADPH oxidase complex. NADPH oxidase complex generates superoxide, a reactive molecule involved in various cellular signaling pathways and immune responses. Mox1 shows predominant expression in colon, with lower levels in uterus and prostate, and demonstrates upregulation in vascular smooth muscle cells responding to platelet-derived growth factor stimulation. Such expression patterns suggest Mox1′s regulatory role in NADPH oxidase activity, particularly where reactive oxygen species are critical for cellular signaling and adaptation to hypoxic conditions. Distinct expression patterns of Mox1 and gp91 phox indicate potential functional divergence, with Mox1 possibly serving as a modulator of oxidative stress responses in specific tissues.

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Mox1 Antibody (C-10) References:

1. O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase.  |  Archer, SL., et al. 1999. Proc Natl Acad Sci U S A. 96: 7944-9. PMID: 10393927
2. The p67(phox) activation domain regulates electron flow from NADPH to flavin in flavocytochrome b(558).  |  Nisimoto, Y., et al. 1999. J Biol Chem. 274: 22999-3005. PMID: 10438466
3. Cell transformation by the superoxide-generating oxidase Mox1.  |  Suh, YA., et al. 1999. Nature. 401: 79-82. PMID: 10485709
4. Superoxide generation in transformed B-lymphocytes from patients with severe, malignant osteopetrosis.  |  Yang, S., et al. 1999. Mol Cell Biochem. 199: 15-24. PMID: 10544947
5. Identification of a functional leukocyte-type NADPH oxidase in human endothelial cells:a potential atherogenic source of reactive oxygen species.  |  Meyer, JW., et al. 1999. Endothelium. 7: 11-22. PMID: 10599557
6. Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos.  |  Candia, AF., et al. 1992. Development. 116: 1123-36. PMID: 1363541
7. Crystal structure of Mox-1, a unique plasmid-mediated class C β-lactamase with hydrolytic activity towards moxalactam.  |  Oguri, T., et al. 2014. Antimicrob Agents Chemother. 58: 3914-20. PMID: 24777102
8. RFLP and mapping of human MOX-1 gene on chromosome 3.  |  Douglas, J., et al. 1988. Nucleic Acids Res. 16: 9067. PMID: 2902568
9. The arachidonate-activable, NADPH oxidase-associated H+ channel. Evidence that gp91-phox functions as an essential part of the channel.  |  Henderson, LM., et al. 1995. J Biol Chem. 270: 5909-16. PMID: 7890722
10. p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells.  |  Ushio-Fukai, M., et al. 1996. J Biol Chem. 271: 23317-21. PMID: 8798532
11. Differential localization of Mox-1 and Mox-2 proteins indicates distinct roles during development.  |  Candia, AF. and Wright, CV. 1996. Int J Dev Biol. 40: 1179-84. PMID: 9032023
12. The human homeobox genes MSX-1, MSX-2, and MOX-1 are differentially expressed in the dermis and epidermis in fetal and adult skin.  |  Stelnicki, EJ., et al. 1997. Differentiation. 62: 33-41. PMID: 9373945

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mox1 Antibody (C-10) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-Mox1 Antibody (C-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mox1 Antibody (C-10) Specifications

Alternate Product Name: NADPH oxidase 1 (NOX1)

Product Clone Name: C-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 121-195

Epitope Target: Mox1

Epitope Species: human

Product Reactivity/Detection: Mox1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for Mox1 Antibody (C-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin