MOR-1 Antibody (D-12): sc-515933

MOR-1 Antibody (D-12) is a mouse monoclonal IgM kappa light chain antibody that detects MOR-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MOR-1 (D-12) antibody is available as the non-conjugated form. MOR-1 protein, also known as the mu-opioid receptor, plays a crucial role in mediating the effects of endogenous opioid peptides and exogenous opiates, such as morphine, by functioning as a receptor for beta-endorphin. MOR-1 is primarily located in the central nervous system and is integral to the modulation of pain, reward, and addictive behaviors. MOR-1′s location in the cell is underscored by involvement in the inhibition of neurotransmitter release, which is achieved through the activation of G protein-coupled signaling pathways that reduce calcium ion influx and enhance potassium ion conductance. This mechanism not only influences instinctive behaviors and emotional responses but also highlights the therapeutic potential of targeting MOR-1 in pain management and addiction treatment. The identification of MOR-1, along with homologous counterparts DOR-1 and KOR-1, has significantly advanced our understanding of the opioid receptor superfamily and its diverse physiological roles.

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MOR-1 Antibody (D-12) References:

1. Comparative immunohistochemical distributions of carboxy terminus epitopes from the mu-opioid receptor splice variants MOR-1D, MOR-1 and MOR-1C in the mouse and rat CNS.  |  Abbadie, C., et al. 2000. Neuroscience. 100: 141-53. PMID: 10996465
2. Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene.  |  Pan, YX., et al. 2001. Proc Natl Acad Sci U S A. 98: 14084-9. PMID: 11717463
3. The MOR-1 opioid receptor regulates glucose homeostasis by modulating insulin secretion.  |  Wen, T., et al. 2009. Mol Endocrinol. 23: 671-8. PMID: 19221053
4. Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity.  |  Chang, KJ. and Cuatrecasas, P. 1979. J Biol Chem. 254: 2610-8. PMID: 218947
5. Mu-, delta- and kappa-opioid receptor-mediated inhibition of neurotransmitter release and adenylate cyclase activity in rat brain slices: studies with fentanyl isothiocyanate.  |  Schoffelmeer, AN., et al. 1988. Eur J Pharmacol. 154: 169-78. PMID: 2906610
6. Mu and kappa opioids inhibit transmitter release by different mechanisms.  |  Cherubini, E. and North, RA. 1985. Proc Natl Acad Sci U S A. 82: 1860-3. PMID: 2984670
7. Mu Opioid Receptor 1 (MOR-1) Expression in Colorectal Cancer and Oncological Long-Term Outcomes: A Five-Year Retrospective Longitudinal Cohort Study.  |  Díaz-Cambronero, O., et al. 2020. Cancers (Basel). 12: PMID: 31948099
8. Molecular biology and pharmacology of cloned opioid receptors.  |  Knapp, RJ., et al. 1995. FASEB J. 9: 516-25. PMID: 7737460
9. Molecular biology of the opioid receptors: structures, functions and distributions.  |  Minami, M. and Satoh, M. 1995. Neurosci Res. 23: 121-45. PMID: 8532211
10. k-Opioid receptor activation of a dendrotoxin-sensitive potassium channel mediates presynaptic inhibition of mossy fiber neurotransmitter release.  |  Simmons, ML. and Chavkin, C. 1996. Mol Pharmacol. 50: 80-5. PMID: 8700123
11. Molecular pharmacology of the opioid receptors.  |  Satoh, M. and Minami, M. 1995. Pharmacol Ther. 68: 343-64. PMID: 8788562
12. Molecular biology of opioid receptors: recent advances.  |  Singh, VK., et al. 1997. Neuroimmunomodulation. 4: 285-97. PMID: 9650823

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MOR-1 Antibody (D-12) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-MOR-1 Antibody (D-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MOR-1 Antibody (D-12) Specifications

Alternate Product Name: MOR-1

Product Clone Name: D-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 26-50

Epitope Target: MOR-1

Epitope Species: human

Product Reactivity/Detection: MOR-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for MOR-1 Antibody (D-12): N/A