MOCS1 Antibody (G-6): sc-398094
- MOCS1 Antibody (G-6) is a mouse monoclonal IgG1 κ MOCS1 antibody provided at 200 µg/ml
- raised against amino acids 87-385 mapping at the C-terminus of MOCS1 of human origin
- MOCS1 Antibody (G-6) is recommended for detection of MOCS1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MOCS1 Antibody (G-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MOCS1 Antibody (G-6) for WB applications. These reagents are now offered in bundles with MOCS1 Antibody (G-6) (see ordering information below).
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MOCS1 Antibody (G-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects MOCS1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MOCS1 (G-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MOCS1, also known as molybdenum cofactor synthesis 1, plays a crucial role in the biosynthesis of molybdenum cofactor and molybdopterin, which are essential for the activity of several key enzymes involved in carbon, nitrogen, and sulfur metabolism. MOCS1 is located in the cytoplasm and facilitates the proper functioning of enzymes that catalyze important biochemical transformations. MOCS1 exists as eight widely expressed isoforms, with MOCS1A and MOCS1B forming a heterooligomer, and mutations in the MOCS1 gene can lead to molybdenum cofactor deficiency type A, a severe autosomal recessive disorder characterized by neurological damage and early childhood mortality. The conservation of the molybdenum cofactor biosynthetic pathway across different organisms underscores MOCS1′s fundamental importance in metabolic processes, making anti-MOCS1 antibody (G-6) an invaluable tool for researchers studying these critical pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MOCS1 Antibody (G-6) References:
- Human molybdopterin synthase gene: genomic structure and mutations in molybdenum cofactor deficiency type B. | Reiss, J., et al. 1999. Am J Hum Genet. 64: 706-11. PMID: 10053004
- Molybdenum cofactor deficiency: first prenatal genetic analysis. | Reiss, J., et al. 1999. Prenat Diagn. 19: 386-8. PMID: 10327149
- The bicistronic MOCS1 gene has alternative start codons on two mutually exclusive exons. | Gross-Hardt, S. and Reiss, J. 2002. Mol Genet Metab. 76: 340-3. PMID: 12208140
- Mutations in the molybdenum cofactor biosynthetic genes MOCS1, MOCS2, and GEPH. | Reiss, J. and Johnson, JL. 2003. Hum Mutat. 21: 569-76. PMID: 12754701
- Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis. | Hänzelmann, P., et al. 2004. J Biol Chem. 279: 34721-32. PMID: 15180982
- Effect of allopurinol on the xanthinuria in a patient with molybdenum cofactor deficiency. | van Gennip, AH., et al. 1994. Adv Exp Med Biol. 370: 375-8. PMID: 7660932
- Localization of a gene for molybdenum cofactor deficiency, on the short arm of chromosome 6, by homozygosity mapping. | Shalata, A., et al. 1998. Am J Hum Genet. 63: 148-54. PMID: 9634514
- Mutations in a polycistronic nuclear gene associated with molybdenum cofactor deficiency. | Reiss, J., et al. 1998. Nat Genet. 20: 51-3. PMID: 9731530
- Genomic structure and mutational spectrum of the bicistronic MOCS1 gene defective in molybdenum cofactor deficiency type A. | Reiss, J., et al. 1998. Hum Genet. 103: 639-44. PMID: 9921896
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MOCS1 Antibody (G-6) | sc-398094 | 200 µg/ml | $322.00 | |||
MOCS1 Antibody (G-6): m-IgG Fc BP-HRP Bundle | sc-527738 | 200 µg Ab; 10 µg BP | $361.00 | |||
MOCS1 Antibody (G-6): m-IgG1 BP-HRP Bundle | sc-533111 | 200 µg Ab; 20 µg BP | $361.00 | |||
MOCS1 Antibody (G-6) AC | sc-398094 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MOCS1 Antibody (G-6) HRP | sc-398094 HRP | 200 µg/ml | $322.00 | |||
MOCS1 Antibody (G-6) FITC | sc-398094 FITC | 200 µg/ml | $336.00 | |||
MOCS1 Antibody (G-6) PE | sc-398094 PE | 200 µg/ml | $349.00 | |||
MOCS1 Antibody (G-6) Alexa Fluor® 488 | sc-398094 AF488 | 200 µg/ml | $364.00 | |||
MOCS1 Antibody (G-6) Alexa Fluor® 546 | sc-398094 AF546 | 200 µg/ml | $364.00 | |||
MOCS1 Antibody (G-6) Alexa Fluor® 594 | sc-398094 AF594 | 200 µg/ml | $364.00 | |||
MOCS1 Antibody (G-6) Alexa Fluor® 647 | sc-398094 AF647 | 200 µg/ml | $364.00 | |||
MOCS1 Antibody (G-6) Alexa Fluor® 680 | sc-398094 AF680 | 200 µg/ml | $364.00 | |||
MOCS1 Antibody (G-6) Alexa Fluor® 790 | sc-398094 AF790 | 200 µg/ml | $364.00 |