MN1 Antibody (A-4): sc-390869
- MN1 Antibody (A-4) is a mouse monoclonal IgG1 κ MN1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1021-1320 mapping at the C-terminus of MN1 of human origin
- MN1 Antibody (A-4) is recommended for detection of MN1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MN1 Antibody (A-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-390869 X, 200 µg/0.1 ml)
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MN1 Antibody (A-4) for WB applications. These reagents are now offered in bundles with MN1 Antibody (A-4) (see ordering information below).
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SEE ALSO...
MN1 Antibody (A-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects MN1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-MN1 antibody (A-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The MN1 gene, located on chromosome 22, encodes a 1,319 amino acid protein that plays a crucial role in transcriptional regulation and cellular differentiation. MN1 (A-4) monoclonal antibody has proven valuable in studying MN1′s involvement in myeloid leukemia through fusion with the ETV6/TEL gene, resulting in the MN1-TEL fusion protein, which acts as a potent transcription factor with transforming activity. This fusion protein is associated with the translocation (12;22)(p13;q11), highlighting MN1′s importance in oncogenesis. Additionally, defects in the MN1 gene have been implicated in the pathogenesis of meningiomas, which are slowly growing benign tumors arising from the arachnoidal cap cells of the leptomeninges, the protective membranes covering the brain and spinal cord. MN1 (A-4) antibody′s ability to effectively detect MN1 across multiple species and applications makes this reagent an invaluable tool for researchers studying its role in cancer and cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MN1 Antibody (A-4) References:
- The MN1-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity. | Buijs, A., et al. 2000. Mol Cell Biol. 20: 9281-93. PMID: 11094079
- The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription. | van Wely, KH., et al. 2003. Oncogene. 22: 699-709. PMID: 12569362
- Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics. | Galmarini, CM., et al. 2003. Br J Cancer. 88: 1793-9. PMID: 12771997
- Expression of the MN1-TEL fusion protein in the human UCSD/AML1 leukemic cell line. | Valle, VD., et al. 2004. Leukemia. 18: 1558-60. PMID: 15229617
- A new complex rearrangement involving the ETV6, LOC115548, and MN1 genes in a case of acute myeloid leukemia. | Belloni, E., et al. 2004. Genes Chromosomes Cancer. 41: 272-7. PMID: 15334551
- Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma. | Lekanne Deprez, RH., et al. 1995. Oncogene. 10: 1521-8. PMID: 7731706
- Two unbalanced translocations, t(12;22)(p13;q11) and t(12;?)(p13;?), in an aggressive chronic B-cell leukemia: TEL gene analysis using FISH. | Conchon, M., et al. 1997. Cancer Genet Cytogenet. 95: 137-40. PMID: 9169030
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MN1 Antibody (A-4) | sc-390869 | 200 µg/ml | $322.00 | |||
MN1 Antibody (A-4): m-IgGκ BP-HRP Bundle | sc-523718 | 200 µg Ab, 40 µg BP | $361.00 | |||
MN1 Antibody (A-4): m-IgG1 BP-HRP Bundle | sc-533604 | 200 µg Ab; 20 µg BP | $361.00 | |||
MN1 Antibody (A-4) X | sc-390869 X | 200 µg/0.1 ml | $322.00 | |||
MN1 Antibody (A-4) AC | sc-390869 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MN1 Antibody (A-4) HRP | sc-390869 HRP | 200 µg/ml | $322.00 | |||
MN1 Antibody (A-4) FITC | sc-390869 FITC | 200 µg/ml | $336.00 | |||
MN1 Antibody (A-4) PE | sc-390869 PE | 200 µg/ml | $349.00 | |||
MN1 Antibody (A-4) Alexa Fluor® 488 | sc-390869 AF488 | 200 µg/ml | $364.00 | |||
MN1 Antibody (A-4) Alexa Fluor® 546 | sc-390869 AF546 | 200 µg/ml | $364.00 | |||
MN1 Antibody (A-4) Alexa Fluor® 594 | sc-390869 AF594 | 200 µg/ml | $364.00 | |||
MN1 Antibody (A-4) Alexa Fluor® 647 | sc-390869 AF647 | 200 µg/ml | $364.00 | |||
MN1 Antibody (A-4) Alexa Fluor® 680 | sc-390869 AF680 | 200 µg/ml | $364.00 | |||
MN1 Antibody (A-4) Alexa Fluor® 790 | sc-390869 AF790 | 200 µg/ml | $364.00 |