Mms2 Antibody (2H11): sc-58391
- Mms2 Antibody (2H11) is a mouse monoclonal IgG1 Mms2 antibody provided at 200 µg/ml
- raised against full length Mms2 of human origin
- recommended for detection of Mms2 of mouse, rat and human origin by WB, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Mms2 Antibody (2H11). This work is in progress.
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Mms2 Antibody (2H11) is a mouse monoclonal IgG1 antibody that detects Mms2 protein of mouse, rat, and human origin by western blotting (WB), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Mms2 antibody (2H11) is available as a non-conjugated format. Mms2 protein plays a crucial role in DNA damage response by participating in polyubiquitin chain assembly, essential for signaling pathways that regulate DNA repair mechanisms. Specifically, Mms2 forms a complex with UBC13, facilitating Lysine 63-linked polyubiquitin chain formation vital for repair protein recruitment to DNA damage sites. This function helps maintain genomic stability and prevents mutation accumulation that could lead to cancer. Mms2 interaction with other proteins involved in ubiquitin-proteasome system underscores significance in cellular processes, including protein degradation regulation and signaling pathway modulation. Using anti-Mms2 antibody (2H11) in research can provide valuable insights into DNA repair mechanisms and broader implications of ubiquitin signaling in cellular health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Mms2 Antibody (2H11) References:
- Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. | Hofmann, RM. and Pickart, CM. 1999. Cell. 96: 645-53. PMID: 10089880
- Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. | Deng, L., et al. 2000. Cell. 103: 351-61. PMID: 11057907
- CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter. | Rothofsky, ML. and Lin, SL. 1997. Gene. 195: 141-9. PMID: 9305758
- Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells. | Sancho, E., et al. 1998. Mol Cell Biol. 18: 576-89. PMID: 9418904
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mms2 Antibody (2H11) | sc-58391 | 200 µg/ml | $316.00 |