Molecular structure of MMP Inhibitor III, CAS Number: 927827-98-3
MMP Inhibitor III (CAS 927827-98-3)
Alternate Names:
N′-hydroxy-N-[1-(methylcarbamoyl)-3-phenyl-propyl]-2-(2-methylpropyl)butanediamide
Application:
MMP Inhibitor III is a broad-spectrum cell-permeable, reversible inhibitor of MMPs.
CAS Number:
927827-98-3
Purity:
≥90%
Molecular Weight:
363.5
Molecular Formula:
C19H29N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MMP Inhibitor III is a homophenylalanine-hydroxamic acid based broad-spectrum cell-permeable, reversible inhibitor of matrix metalloproteinases (supplied as a racemic mixture). MMP Inhibitor III has been reported to inhibit MMP-1 (IC50 = 7.4 nM), MMP-2 (IC50 = 2.3 nM), MMP-3 (IC50 = 135 nM), MMP-7 (IC50 = 10-100 nM), and MMP-13 (IC50 = 1-10 nM).
MMP Inhibitor III (CAS 927827-98-3) References
- Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases. | Heljasvaara, R., et al. 2005. Exp Cell Res. 307: 292-304. PMID: 15950618
- Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14). | Covington, MD., et al. 2006. Am J Physiol Renal Physiol. 290: F43-51. PMID: 16077081
- Collagenase-2 and -3 mediate epidermal growth factor receptor transactivation by bradykinin B2 receptor in kidney cells. | Mukhin, YV., et al. 2006. J Pharmacol Exp Ther. 318: 1033-43. PMID: 16717107
- Triple-helical transition state analogues: a new class of selective matrix metalloproteinase inhibitors. | Lauer-Fields, J., et al. 2007. J Am Chem Soc. 129: 10408-17. PMID: 17672455
- Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate. | Lauer-Fields, JL., et al. 2008. Anal Biochem. 373: 43-51. PMID: 17949675
- Selective modulation of matrix metalloproteinase 9 (MMP-9) functions via exosite inhibition. | Lauer-Fields, JL., et al. 2008. J Biol Chem. 283: 20087-95. PMID: 18499673
- Comparison of metalloproteinase protein and activity profiling. | Giricz, O., et al. 2011. Anal Biochem. 409: 37-45. PMID: 20920458
- Natural products as a gold mine for selective matrix metalloproteinases inhibitors. | Wang, L., et al. 2012. Bioorg Med Chem. 20: 4164-71. PMID: 22658537
- The endogenous protease inhibitor TIMP-1 mediates protection and recovery from cutaneous photodamage. | Yokose, U., et al. 2012. J Invest Dermatol. 132: 2800-9. PMID: 22718114
- Resveratrol attenuates matrix metalloproteinase-9 and -2-regulated differentiation of HTB94 chondrosarcoma cells through the p38 kinase and JNK pathways. | Gweon, EJ. and Kim, SJ. 2014. Oncol Rep. 32: 71-8. PMID: 24841706
- Inhibition of TGF-β signaling, invasion, and growth of cutaneous squamous cell carcinoma by PLX8394. | Siljamäki, E., et al. 2023. Oncogene. 42: 3633-3647. PMID: 37864034
Inhibitor of:
MMP-1, MMP-13, MMP-2, MMP-7, and Protease.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MMP Inhibitor III, 1 mg | sc-311427 | 1 mg | $264.00 |