MMP-10 Antibody (LA-12): sc-80197
- MMP-10 Antibody (LA-12) is a mouse monoclonal IgG1, cited in 6 publications, provided at 100 µg/ml
- raised against amino acids 99-486 of MMP-10 of human origin
- recommended for detection of pro and mature MMP-10 of human origin by WB, IP, IF, IHC(P) and FCM; may cross-react with MMP-3; non cross-reactive with MMP-1, MMP-2, MMP-7, MMP-8, MMP-12 or MMP-13
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MMP-10 Antibody (LA-12). This work is in progress.
MMP-10 Antibody (LA-12) is a mouse monoclonal IgG1 antibody that detects MMP-10 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). MMP-10, also known as Stromelysin-2, is a member of the matrix metalloproteinase family, which plays a crucial role in the degradation of extracellular matrix components such as collagen, gelatin, fibronectin, laminin, and proteoglycans. MMP-10 is primarily expressed in the small intestine, with lower levels found in the lung and heart, highlighting its importance in tissue remodeling and repair. MMP-10′s enzymatic activity is particularly significant as it facilitates the breakdown of fibronectin and various types of gelatin, although its effect on collagens III, IV, and V is relatively weak. Notably, MMP-10 expression is upregulated in ras-transformed HaCaT II-4 keratinocytes, which promotes epithelial-to-mesenchymal transition, a process that is critical in cancer progression and metastasis. MMP-10′s ability to modulate the extracellular matrix underscores its potential as a therapeutic target in cancer and other diseases characterized by aberrant tissue remodeling.
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MMP-10 Antibody (LA-12) References:
- Metalloproteinases and atherothrombosis: MMP-10 mediates vascular remodeling promoted by inflammatory stimuli. | Rodriguez, JA., et al. 2008. Front Biosci. 13: 2916-21. PMID: 17981764
- Evaluation of MMP-1, MMP-10, TIMP-1, a-SMA and TGF-b1 in angiofibromas of tuberous sclerosis. | De Jesus Araújo, L., et al. 2011. Minerva Stomatol. 60: 25-33. PMID: 21252847
- Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure. | Batra, J., et al. 2012. J Biol Chem. 287: 15935-46. PMID: 22427646
- Application of MMP-7 and MMP-10 in assisting the diagnosis of malignant pleural effusion. | Cheng, D., et al. 2012. Asian Pac J Cancer Prev. 13: 505-9. PMID: 22524815
- MMP-1 and Pro-MMP-10 as potential urinary pharmacodynamic biomarkers of FGFR3-targeted therapy in patients with bladder cancer. | Du, X., et al. 2014. Clin Cancer Res. 20: 6324-35. PMID: 25326231
- MMP-10 Regulates Collagenolytic Activity of Alternatively Activated Resident Macrophages. | Rohani, MG., et al. 2015. J Invest Dermatol. 135: 2377-2384. PMID: 25927164
- MMP-10, MMP-7, TIMP-1 and TIMP-2 mRNA expression in esophageal cancer. | Juchniewicz, A., et al. 2017. Acta Biochim Pol. 64: 295-299. PMID: 28510611
- A Role for MMP-10 (Matrix Metalloproteinase-10) in Calcific Aortic Valve Stenosis. | Matilla, L., et al. 2020. Arterioscler Thromb Vasc Biol. 40: 1370-1382. PMID: 32188274
- MMP-10 from M1 macrophages promotes pulmonary vascular remodeling and pulmonary arterial hypertension. | Chi, PL., et al. 2022. Int J Biol Sci. 18: 331-348. PMID: 34975336
- MMP-10 Deficiency Effects Differentiation and Death of Chondrocytes Associated with Endochondral Osteogenesis in an Endemic Osteoarthritis. | Zhang, D., et al. 2022. Cartilage. 13: 19476035221109226. PMID: 35818290
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MMP-10 Antibody (LA-12) | sc-80197 | 100 µg/ml | $316.00 |