MLL Antibody (D-3): sc-377274
- MLL Antibody (D-3) is a mouse monoclonal IgG2b κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 3301-3600 mapping within an internal region of MLL of human origin
- MLL Antibody (D-3) is recommended for detection of MLL of human origin by WB, IP, IF and ELISA
- Anti-MLL Antibody (D-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for MLL Antibody (D-3) for WB applications. This reagent is now offered in a bundle with MLL Antibody (D-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
MLL Antibody (D-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects MLL protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-MLL antibody (D-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MLL protein, also known as myeloid/lymphoid leukemia, plays a crucial role in regulating embryonic and hematopoietic development, making MLL essential for proper cellular differentiation and proliferation. Notably, MLL is involved in chromosomal translocations that lead to acute myeloid leukemia, particularly through interactions with other proteins such as ELL (11-19 lysine-rich leukemia protein), which enhances RNA polymerase II elongation and transcriptional efficiency. The gene encoding MLL is located on chromosome 11q23, and MLL dysregulation can have significant implications in cancer biology. MLL (D-3) antibody is an invaluable tool for researchers studying the mechanisms of gene expression regulation and the pathogenesis of leukemia, providing insights into the molecular underpinnings of these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MLL Antibody (D-3) References:
- The role of MLL in hematopoiesis and leukemia. | Ernst, P., et al. 2002. Curr Opin Hematol. 9: 282-7. PMID: 12042701
- Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation. | Ono, R., et al. 2009. Leukemia. 23: 2197-209. PMID: 19710696
- Disordered epigenetic regulation in MLL-related leukemia. | Zhang, Y., et al. 2012. Int J Hematol. 96: 428-37. PMID: 23054645
- MicroRNAs mark in the MLL-rearranged leukemia. | Benetatos, L. and Vartholomatos, G. 2013. Ann Hematol. 92: 1439-50. PMID: 23728610
- Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia. | Liang, K., et al. 2017. Cell. 168: 59-72.e13. PMID: 28065413
- MLL is essential for NUP98-HOXA9-induced leukemia. | Shima, Y., et al. 2017. Leukemia. 31: 2200-2210. PMID: 28210005
- MLL-rearranged acute myeloid leukemia: Influence of the genetic partner in allo-HSCT response and prognostic factor of MLL 3' region mRNA expression. | Burillo-Sanz, S., et al. 2018. Eur J Haematol. 100: 436-443. PMID: 29384595
- Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological Interventions. | Chan, AKN. and Chen, CW. 2019. Front Cell Dev Biol. 7: 81. PMID: 31157223
- MLL fusion proteins and transcriptional control. | Slany, RK. 2020. Biochim Biophys Acta Gene Regul Mech. 1863: 194503. PMID: 32061883
- 11q23/MLL rearrangements in adult acute leukemia. | Zotova, OV., et al. 2021. Exp Oncol. 43: 229-233. PMID: 34591430
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MLL Antibody (D-3) | sc-377274 | 200 µg/ml | $322.00 | |||
MLL Antibody (D-3): m-IgGκ BP-HRP Bundle | sc-523260 | 200 µg Ab, 40 µg BP | $361.00 | |||
MLL Antibody (D-3) AC | sc-377274 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MLL Antibody (D-3) HRP | sc-377274 HRP | 200 µg/ml | $322.00 | |||
MLL Antibody (D-3) FITC | sc-377274 FITC | 200 µg/ml | $336.00 | |||
MLL Antibody (D-3) PE | sc-377274 PE | 200 µg/ml | $349.00 | |||
MLL Antibody (D-3) Alexa Fluor® 488 | sc-377274 AF488 | 200 µg/ml | $364.00 | |||
MLL Antibody (D-3) Alexa Fluor® 546 | sc-377274 AF546 | 200 µg/ml | $364.00 | |||
MLL Antibody (D-3) Alexa Fluor® 594 | sc-377274 AF594 | 200 µg/ml | $364.00 | |||
MLL Antibody (D-3) Alexa Fluor® 647 | sc-377274 AF647 | 200 µg/ml | $364.00 | |||
MLL Antibody (D-3) Alexa Fluor® 680 | sc-377274 AF680 | 200 µg/ml | $364.00 | |||
MLL Antibody (D-3) Alexa Fluor® 790 | sc-377274 AF790 | 200 µg/ml | $364.00 |