Este anticuerpo policlonal ha dejado de fabricarse. Consulta nuestro anticuerpo monoclonal recomendado MLH1 (B-12) (se muestran datos de muestra).
MLH1 Anticuerpo (N-20): sc-581
- MLH1 Anticuerpo N-20es un policlonal de conejo IgG proporcionado como 100 µg/ml
- epítopo localizado en el N-terminus de MLH1 de origen human
- Anticuerpo policlonal discontinuado
DNA-mismatch repair (MMR) is an essential process in maintaining genetic stability. Lack of a functional DNA-mismatch repair pathway is a common characteristic of several different types of human cancers, either due to an MMR gene mutation or promoter methylation gene silencing. MLH1 is an integral part of the protein complex responsible for mismatch repair that is expressed in lymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid and gall bladder and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectal cancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Certain cancer cell lines, including leukemia CCRF-CEM, colon HCT 116 and KM12, and ovarian cancers SK-OV-3 and IGROV-1, show complete deficiency of MLH1, while MLH1 is expressed in 60% of melanomas, 70% of noninvasive squamous cell carcinomas and 30% of invasive squamous cell carcinomas.
Información sobre pedidos
MLH1 (B-12): sc-271978 [ Monoclonal recomendado como alternativa a MLH1 (N-20) ]
| Nombre del producto | Número de catálogo | UNIDAD | Precio | CANTIDAD | Favoritos | |
MLH1 Anticuerpo (B-12) | sc-271978 | 200 µg/ml | $322.00 | |||
Paquete de MLH1 (B-12): m-IgG Fc BP-HRP | sc-529295 | 200 µg Ab; 10 µg BP | $361.00 | |||
Paquete de MLH1 (B-12): m-IgGκ BP-HRP | sc-522112 | 200 µg Ab, 40 µg BP | $361.00 | |||
Paquete de MLH1 (B-12): m-IgG1 BP-HRP | sc-543435 | 200 µg Ab; 20 µg BP | $361.00 | |||
MLH1 Anticuerpo (B-12) AC | sc-271978 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MLH1 Anticuerpo (B-12) HRP | sc-271978 HRP | 200 µg/ml | $322.00 | |||
MLH1 Anticuerpo (B-12) FITC | sc-271978 FITC | 200 µg/ml | $336.00 | |||
MLH1 Anticuerpo (B-12) PE | sc-271978 PE | 200 µg/ml | $349.00 | |||
MLH1 Anticuerpo (B-12) Alexa Fluor® 488 | sc-271978 AF488 | 200 µg/ml | $364.00 | |||
MLH1 Anticuerpo (B-12) Alexa Fluor® 546 | sc-271978 AF546 | 200 µg/ml | $364.00 | |||
MLH1 Anticuerpo (B-12) Alexa Fluor® 594 | sc-271978 AF594 | 200 µg/ml | $364.00 | |||
MLH1 Anticuerpo (B-12) Alexa Fluor® 647 | sc-271978 AF647 | 200 µg/ml | $364.00 | |||
MLH1 Anticuerpo (B-12) Alexa Fluor® 680 | sc-271978 AF680 | 200 µg/ml | $364.00 | |||
MLH1 Anticuerpo (B-12) Alexa Fluor® 790 | sc-271978 AF790 | 200 µg/ml | $364.00 | |||
MLH1 (B-12) péptido neutralizante | sc-271978 P | 100 µg/0.5 ml | $69.00 |