ML 265 (CAS 1221186-53-3)
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Alternate Names:
TEPP 46; ML-265; ML265
Application:
ML 265 is an activator of PKM2.
CAS Number:
1221186-53-3
Molecular Weight:
372.5
Molecular Formula:
C17H16N4O2S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ML 265 is an activator of PKM2.
ML 265 (CAS 1221186-53-3) References
- The importance of species sorting differs between habitat generalists and specialists in bacterial communities. | Székely, AJ. and Langenheder, S. 2014. FEMS Microbiol Ecol. 87: 102-12. PMID: 23991811
- Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity. | Watanabe, R., et al. 2017. J Clin Invest. 127: 2725-2738. PMID: 28604383
- Caloric Restriction Mimetic 2-Deoxyglucose Alleviated Inflammatory Lung Injury via Suppressing Nuclear Pyruvate Kinase M2-Signal Transducer and Activator of Transcription 3 Pathway. | Hu, K., et al. 2018. Front Immunol. 9: 426. PMID: 29552018
- Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells. | Stone, OA., et al. 2018. Nat Commun. 9: 4077. PMID: 30301887
- Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis. | Zhang, M., et al. 2019. Cell Commun Signal. 17: 23. PMID: 30866966
- Pyruvate kinase M2 in lung APCs regulates Alternaria-induced airway inflammation. | Jaiswal, AK., et al. 2020. Immunobiology. 225: 151956. PMID: 32747016
- The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis. | Nayak, MK., et al. 2021. Blood. 137: 1658-1668. PMID: 33027814
- Pyruvate Kinase M2 Coordinates Metabolism Switch between Glycolysis and Glutaminolysis in Cancer Cells. | Li, L., et al. 2020. iScience. 23: 101684. PMID: 33196019
- Smooth Muscle Cell-Specific PKM2 (Pyruvate Kinase Muscle 2) Promotes Smooth Muscle Cell Phenotypic Switching and Neointimal Hyperplasia. | Jain, M., et al. 2021. Arterioscler Thromb Vasc Biol. 41: 1724-1737. PMID: 33691477
- Non-Metabolic Functions of PKM2 Contribute to Cervical Cancer Cell Proliferation Induced by the HPV16 E7 Oncoprotein. | Lee, SA., et al. 2021. Viruses. 13: PMID: 33800513
- Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis. | Doddapattar, P., et al. 2022. Circ Res. 130: 1289-1305. PMID: 35400205
- OGA activated glycopeptide-based nano-activator to activate PKM2 tetramerization for switching catabolic pathways and sensitizing chemotherapy resistance. | Hou, DY., et al. 2022. Biomaterials. 284: 121523. PMID: 35462306
- Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation. | Chen, LL., et al. 2022. Eur J Pharmacol. 936: 175352. PMID: 36309049
- PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism. | Lin, H., et al. 2023. Eur J Med Chem. 249: 115166. PMID: 36731272
Activator of:
PKM2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ML 265, 5 mg | sc-492599 | 5 mg | $208.00 |