PKM2 Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Fructose 1,6-bisphosphate trisodium salt octahydrate | 81028-91-3 | sc-221476 sc-221476A | 1 g 5 g | $57.00 $97.00 | 1 | |
D-Fructose 1,6-bisphosphate trisodium salt octahydrate serves as a crucial allosteric regulator in metabolic pathways, particularly in glycolysis. Its unique trisodium salt form enhances solubility, allowing for effective interaction with enzymes. The octahydrate structure provides a dynamic hydration environment, which stabilizes transient enzyme complexes. This compound's ability to modulate enzyme activity through specific molecular interactions underscores its role in cellular energy regulation and metabolic flux. | ||||||
ML 265 | 1221186-53-3 | sc-492599 | 5 mg | $208.00 | 1 | |
ML 265 is a selective activator of pyruvate kinase M2 (PKM2), influencing its dimer-tetramer equilibrium. This compound enhances PKM2's enzymatic activity by promoting its tetrameric form, which is crucial for efficient glycolytic flux. The unique binding interactions of ML 265 stabilize the enzyme's active conformation, facilitating substrate access and increasing reaction rates. Its distinct mechanism of action highlights the intricate regulation of metabolic pathways and energy homeostasis. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
Inhibits glycolysis by targeting hexokinase. Cellular metabolic stress might indirectly affect PKM2 expression. | ||||||
Sodium dichloroacetate | 2156-56-1 | sc-203275 sc-203275A | 10 g 50 g | $55.00 $209.00 | 6 | |
Inhibits pyruvate dehydrogenase kinase (PDK), shifting metabolism from glycolysis to oxidative phosphorylation. This metabolic shift could potentially influence PKM2 levels. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Activates AMP-activated protein kinase (AMPK) leading to decreased glycolysis. The metabolic reprogramming might indirectly upregulate PKM2. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Stimulates glucose uptake and metabolism, potentially affecting PKM2 expression in certain contexts. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $64.00 $176.00 | 7 | |
Mimics hypoxic conditions by stabilizing HIF-1α, potentially promoting PKM2 expression under pseudo-hypoxic conditions. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
By inhibiting mTOR, Rapamycin affects cell growth and metabolism, which might indirectly influence PKM2 expression as part of metabolic reprogramming. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
Akt signaling promotes glycolysis, so inhibiting Akt might cause metabolic shifts that could influence PKM2 levels. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
By inhibiting PI3K, Wortmannin affects downstream Akt and mTOR signaling, potentially influencing PKM2 expression due to shifts in cellular metabolism. | ||||||