MISR II Antibody (D-9): sc-377413

MISR II Antibody (D-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects MISR II of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MISR II (D-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MISR II, also known as the anti-Muellerian hormone type-2 receptor, is a 573 amino acid protein encoded by the AMHR2 gene in humans. MISR II is a member of the protein kinase superfamily and specifically belongs to the TKL Ser/Thr protein kinase family and the TGFB receptor subfamily, featuring a single protein kinase domain. Upon binding with its ligand, MISR II forms a receptor complex that includes two type II and two type I transmembrane serine/threonine kinases. The type II receptors phosphorylate and activate the type I receptors, which then undergo autophosphorylation and subsequently bind to and activate Smad transcriptional regulators, playing a crucial role in the regulation of various developmental processes. Defects in the AMHR2 gene are associated with persistent Muellerian duct syndrome type 2 (PMDS-2), a condition characterized by male pseudohermaphroditism due to the failure of Muellerian duct regression in otherwise normal males, highlighting the significance of MISR II in reproductive development and function.

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MISR II Antibody (D-9) References:

1. Autosomal recessive segregation of a truncating mutation of anti-Müllerian type II receptor in a family affected by the persistent Müllerian duct syndrome contrasts with its dominant negative activity in vitro.  |  Messika-Zeitoun, L., et al. 2001. J Clin Endocrinol Metab. 86: 4390-7. PMID: 11549681
2. Conserved Anti-Müllerian Hormone: Anti-Müllerian Hormone Type-2 Receptor Specific Interaction and Intracellular Signaling in Teleosts.  |  Rocha, A., et al. 2016. Biol Reprod. 94: 141. PMID: 27226310
3. Investigation of soluble anti-Müllerian hormone receptor type 2 as a biomarker for diagnosis of female fertility disorders.  |  Olivier, LS., et al. 2019. Reprod Biomed Online. 39: 1017-1025. PMID: 31727499
4. Immunohistochemical characterization of the anti-Müllerian hormone receptor type 2 (AMHR-2) in human testes.  |  Sansone, A., et al. 2020. Endocrine. 68: 215-221. PMID: 32026338
5. Anti-Müllerian Hormone Type II Receptor Expression in Endometrial Cancer Tissue.  |  Gowkielewicz, M., et al. 2020. Cells. 9: PMID: 33080800
6. Genetics of anti-Müllerian hormone and its signaling pathway.  |  Josso, N. and Picard, JY. 2022. Best Pract Res Clin Endocrinol Metab. 36: 101634. PMID: 35249805
7. Expression of Anti-Müllerian Hormone and Its Type 2 Receptor in the Ovary of Pregnant and Cyclic Domestic Cats.  |  Gültiken, N., et al. 2022. Animals (Basel). 12: PMID: 35405866
8. Two male sibs with uterus and Fallopian tubes. A rare, probably inherited disorder.  |  Armendares, S., et al. 1973. Clin Genet. 4: 291-6. PMID: 4148776
9. Insensitivity to anti-müllerian hormone due to a mutation in the human anti-müllerian hormone receptor.  |  Imbeaud, S., et al. 1995. Nat Genet. 11: 382-8. PMID: 7493017
10. A 27 base-pair deletion of the anti-müllerian type II receptor gene is the most common cause of the persistent müllerian duct syndrome.  |  Imbeaud, S., et al. 1996. Hum Mol Genet. 5: 1269-77. PMID: 8872466
11. Genetic analysis of the Müllerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation.  |  Mishina, Y., et al. 1996. Genes Dev. 10: 2577-87. PMID: 8895659
12. The gene encoding anti-müllerian hormone type 2 receptor maps to mouse chromosome 15.  |  Kunieda, T., et al. 1998. Mamm Genome. 9: 259. PMID: 9501316

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MISR II Antibody (D-9) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-MISR II Antibody (D-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MISR II Antibody (D-9) Specifications

Alternate Product Name: MISR II

Product Clone Name: D-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-150

Epitope Target: MISR II

Epitope Species: human

Product Reactivity/Detection: MISR II

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for MISR II Antibody (D-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin