MiRP1 Antibody (H-4): sc-374667
- MiRP1 Antibody (H-4) is a mouse monoclonal IgG1 κ MiRP1 antibody provided at 200 µg/ml
- raised against amino acids 1-70 mapping at the N-terminus of MiRP1 of human origin
- MiRP1 Antibody (H-4) is recommended for detection of MiRP1 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-MiRP1 Antibody (H-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for MiRP1 Antibody (H-4) for WB and IHC(P) applications. This reagent is now offered in a bundle with MiRP1 Antibody (H-4) (see ordering information below).
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MiRP1 Antibody (H-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects MiRP1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MiRP1 (H-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MiRP1, also known as KCNE2, plays a crucial role in regulating cardiac and neuronal excitability by modulating voltage-gated potassium channels. MiRP1 interacts with HERG channel, essential for cardiac repolarization, and proper function is vital for maintaining normal heart rhythm. Mutations in MiRP1 can lead to congenital long QT syndrome, a condition increasing risk of life-threatening arrhythmias. MiRP1 also modulates KCNQ2 channels in the brain, influencing neuronal signaling and excitability. Human MiRP1 gene is located on chromosome 21q22.12, and expression is critical for both cardiac and neuronal health, making MiRP1 a significant target for research in cardiac arrhythmias and neurological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MiRP1 Antibody (H-4) References:
- MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. | Abbott, GW., et al. 1999. Cell. 97: 175-87. PMID: 10219239
- A constitutively open potassium channel formed by KCNQ1 and KCNE3. | Schroeder, BC., et al. 2000. Nature. 403: 196-9. PMID: 10646604
- A common polymorphism associated with antibiotic-induced cardiac arrhythmia. | Sesti, F., et al. 2000. Proc Natl Acad Sci U S A. 97: 10613-8. PMID: 10984545
- M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit. | Tinel, N., et al. 2000. FEBS Lett. 480: 137-41. PMID: 11034315
- KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. | Tinel, N., et al. 2000. EMBO J. 19: 6326-30. PMID: 11101505
- The cardiac K+ channel KCNQ1 is essential for gastric acid secretion. | Grahammer, F., et al. 2001. Gastroenterology. 120: 1363-71. PMID: 11313306
- Cloning of a membrane protein that induces a slow voltage-gated potassium current. | Takumi, T., et al. 1988. Science. 242: 1042-5. PMID: 3194754
- Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. | Wang, Q., et al. 1996. Nat Genet. 12: 17-23. PMID: 8528244
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MiRP1 Antibody (H-4) | sc-374667 | 200 µg/ml | $322.00 | |||
MiRP1 Antibody (H-4): m-IgG Fc BP-HRP Bundle | sc-525986 | 200 µg Ab; 10 µg BP | $361.00 | |||
MiRP1 Antibody (H-4) AC | sc-374667 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MiRP1 Antibody (H-4) HRP | sc-374667 HRP | 200 µg/ml | $322.00 | |||
MiRP1 Antibody (H-4) FITC | sc-374667 FITC | 200 µg/ml | $336.00 | |||
MiRP1 Antibody (H-4) PE | sc-374667 PE | 200 µg/ml | $349.00 | |||
MiRP1 Antibody (H-4) Alexa Fluor® 488 | sc-374667 AF488 | 200 µg/ml | $364.00 | |||
MiRP1 Antibody (H-4) Alexa Fluor® 546 | sc-374667 AF546 | 200 µg/ml | $364.00 | |||
MiRP1 Antibody (H-4) Alexa Fluor® 594 | sc-374667 AF594 | 200 µg/ml | $364.00 | |||
MiRP1 Antibody (H-4) Alexa Fluor® 647 | sc-374667 AF647 | 200 µg/ml | $364.00 | |||
MiRP1 Antibody (H-4) Alexa Fluor® 680 | sc-374667 AF680 | 200 µg/ml | $364.00 | |||
MiRP1 Antibody (H-4) Alexa Fluor® 790 | sc-374667 AF790 | 200 µg/ml | $364.00 |