MIP-2 Antibody (JJ19): sc-80518

MIP-2 Antibody (JJ19) is a mouse monoclonal IgG2b kappa light chain antibody that detects MIP-2 protein of mouse and rat origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-MIP-2 antibody (JJ19) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important chemokine. MIP-2, or macrophage inflammatory protein-2, plays a crucial role in the immune response by acting as a potent chemoattractant for neutrophils and other immune cells, thereby facilitating the recruitment of these cells to sites of inflammation. This function is vital for the body′s ability to respond to infections and tissue damage, making MIP-2 a key player in both innate and adaptive immunity. MIP-2 is primarily secreted by activated macrophages and is involved in various inflammatory processes, including those associated with autoimmune diseases and cancer. Understanding the dynamics of MIP-2 and its interactions with other proteins can provide insights into therapeutic targets for modulating immune responses. MIP-2 (JJ19) antibody is an essential reagent for researchers investigating the complex roles of chemokines in health and disease.

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MIP-2 Antibody (JJ19) References:

1. Dynamics of production of MIP-1alpha, MCP-1 and MIP-2 and potential role of neutralization of these chemokines in the regulation of immune responses during experimental autoimmune neuritis in Lewis rats.  |  Zou, LP., et al. 1999. J Neuroimmunol. 98: 168-75. PMID: 10430050
2. MIP-2 recruits NKT cells to the spleen during tolerance induction.  |  Faunce, DE., et al. 2001. J Immunol. 166: 313-21. PMID: 11123307
3. Enhanced production of macrophage inflammatory protein 2 (MIP-2) by in vitro and in vivo infections with encephalomyocarditis virus and modulation of myocarditis with an antibody against MIP-2.  |  Kishimoto, C., et al. 2001. J Virol. 75: 1294-300. PMID: 11152502
4. Studies on MIP-2 and CXCR2 expression in a mouse model of extrahepatic colorectal metastasis.  |  Kollmar, O., et al. 2007. Eur J Surg Oncol. 33: 803-11. PMID: 17314027
5. Macrophage inflammatory protein-2 (MIP-2)/CXCR2 blockade attenuates acute graft-versus-host disease while preserving graft-versus-leukemia activity.  |  Cho, KA., et al. 2012. Biochem Biophys Res Commun. 426: 558-64. PMID: 22982307
6. Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors.  |  Zipfel, PF., et al. 1989. J Immunol. 142: 1582-90. PMID: 2521882
7. Actions of the chemotactic cytokines MCP-1, MCP-2, MCP-3, RANTES, MIP-1 alpha and MIP-1 beta on human monocytes.  |  Uguccioni, M., et al. 1995. Eur J Immunol. 25: 64-8. PMID: 7531149
8. Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes.  |  Schall, TJ., et al. 1993. J Exp Med. 177: 1821-6. PMID: 7684437
9. Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines.  |  Widmer, U., et al. 1993. J Immunol. 150: 4996-5012. PMID: 8496601
10. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells.  |  Cocchi, F., et al. 1995. Science. 270: 1811-5. PMID: 8525373
11. The role of MIP-1 alpha in inflammation and hematopoiesis.  |  Cook, DN. 1996. J Leukoc Biol. 59: 61-6. PMID: 8558069
12. Beta chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production.  |  Taub, DD., et al. 1996. J Leukoc Biol. 59: 81-9. PMID: 8558072

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MIP-2 Antibody (JJ19) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-MIP-2 Antibody (JJ19) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MIP-2 Antibody (JJ19) Specifications

Alternate Product Name: MIP-2

Product Clone Name: JJ19

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: MIP-2

Epitope Species: rat

Product Reactivity/Detection: MIP-2

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for MIP-2 Antibody (JJ19): N/A

The preferred GROα/β/γ antibody is GROα/β/γ Antibody (A-6): sc-365870.