Molecular structure of (−)-Isoproterenol (+)-bitartrate salt, CAS Number: 54750-10-6
(−)-Isoproterenol (+)-bitartrate salt (CAS 54750-10-6)
Alternate Names:
(−)-Isoprenaline (+)-bitartrate salt
Application:
(−)-Isoproterenol (+)-bitartrate salt is a β-adrenoceptor agonist
CAS Number:
54750-10-6
Purity:
≥98%
Molecular Weight:
361.34
Molecular Formula:
C11H17NO3•C4H6O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
(−)-Isoproterenol (+)-bitartrate salt is a compound that has been the subject of extensive research due to its activity as a beta-adrenergic agonist. In the field of cardiovascular research, it is used to study the response of cardiac tissue to sympathetic nervous system stimulation, providing insights into the mechanisms of heart rate and contractility regulation. Researchers also utilize this compound to explore bronchial dynamics, which is relevant for understanding respiratory function. In molecular biology, the salt form of (−)-Isoproterenol is advantageous for its increased stability and solubility, facilitating its use in various in vitro experiments. Furthermore, the compound is of interest in studies pertaining to signal transduction pathways, specifically those involving cyclic AMP as a secondary messenger.
(−)-Isoproterenol (+)-bitartrate salt (CAS 54750-10-6) References
- Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. | Pierce, KL., et al. 2000. Proc Natl Acad Sci U S A. 97: 1489-94. PMID: 10677489
- Agonist-directed trafficking of porcine alpha(2A)-adrenergic receptor signaling in Chinese hamster ovary cells: l-isoproterenol selectively activates G(s). | Brink, CB., et al. 2000. J Pharmacol Exp Ther. 294: 539-47. PMID: 10900230
- Adrenergic stimulation of osteoclastogenesis mediated by expression of osteoclast differentiation factor in MC3T3-E1 osteoblast-like cells. | Takeuchi, T., et al. 2001. Biochem Pharmacol. 61: 579-86. PMID: 11239501
- Effects of verapamil and elgodipine on isoprenaline-induced metabolic responses in rabbits. | García-Barrado, MJ., et al. 2001. Eur J Pharmacol. 415: 105-15. PMID: 11245858
- Beta-adrenoceptor-induced inhibition of rat splenocyte proliferation: cytokine gene transcription as the target of action. | Xie, Y., et al. 2002. Immunobiology. 206: 345-53. PMID: 12437066
- Exercise restores beta-adrenergic vasorelaxation in aged rat carotid arteries. | Leosco, D., et al. 2003. Am J Physiol Heart Circ Physiol. 285: H369-74. PMID: 12637361
- Effects of beta-adrenergic agonists on bone-resorbing activity in human osteoclast-like cells. | Arai, M., et al. 2003. Biochim Biophys Acta. 1640: 137-42. PMID: 12729923
- Norepinephrine activates extracellular-regulated kinase in cortical neurons. | Tolbert, LM., et al. 2003. Biol Psychiatry. 54: 983-93. PMID: 14625140
- Regulation of cAMP levels in area CA1 of hippocampus by Gi/o-coupled receptors is stimulus dependent in mice. | Vanhoose, AM., et al. 2004. Neurosci Lett. 370: 80-3. PMID: 15489022
- Inhibitory effect of CGRP on osteoclast formation by mouse bone marrow cells treated with isoproterenol. | Ishizuka, K., et al. 2005. Neurosci Lett. 379: 47-51. PMID: 15814197
- Presynaptic alpha-adrenoceptors in median preoptic nucleus modulate inhibitory neurotransmission from subfornical organ and organum vasculosum lamina terminalis. | Kolaj, M. and Renaud, LP. 2007. Am J Physiol Regul Integr Comp Physiol. 292: R1907-15. PMID: 17218440
- Regional heterogeneity of α-adrenoreceptor subtypes in arteriolar networks of mouse skeletal muscle. | Moore, AW., et al. 2010. J Physiol. 588: 4261-74. PMID: 20807785
- β-Adrenergic signaling stimulates osteoclastogenesis via reactive oxygen species. | Kondo, H., et al. 2013. Am J Physiol Endocrinol Metab. 304: E507-15. PMID: 23169789
- Effects of topical adrenergic agents on prostaglandin E2-induced aqueous flare and intraocular pressure elevation in pigmented rabbits. | Nakamura-Shibasaki, M., et al. 2016. Jpn J Ophthalmol. 60: 95-102. PMID: 26832333
Activator of:
AR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(−)-Isoproterenol (+)-bitartrate salt, 100 mg | sc-252926 | 100 mg | $105.00 | |||
(−)-Isoproterenol (+)-bitartrate salt, 500 mg | sc-252926A | 500 mg | $262.00 | |||
(−)-Isoproterenol (+)-bitartrate salt, 1 g | sc-252926D | 1 g | $413.00 | |||
(−)-Isoproterenol (+)-bitartrate salt, 5 g | sc-252926B | 5 g | $2341.00 | |||
(−)-Isoproterenol (+)-bitartrate salt, 10 g | sc-252926C | 10 g | $4474.00 |