MGRN1 Antibody (LM-1A33): sc-134385

MGRN1 Antibody (LM-1A33) is a mouse monoclonal IgG2a kappa light chain antibody that detects MGRN1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-MGRN1 antibody (LM-1A33) is available as a non-conjugated format. MGRN1, also known as mahogunin or RNF156, is a 552 amino acid protein characterized by the presence of a RING-type zinc finger motif, which is crucial for functioning as an E3 ubiquitin-protein ligase. This motif allows MGRN1 to facilitate the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to specific substrate proteins, marking them for degradation via the ubiquitin-proteasome pathway. MGRN1′s ability to undergo autoubiquitination is significant, as this process regulates degradation and plays a vital role in maintaining cellular homeostasis. Additionally, MGRN1 is involved in various cellular processes, including the modulation of signaling pathways and the response to stress, making MGRN1 an important player in cellular regulation. Notably, four isoforms of MGRN1 arise from alternative splicing, which may contribute to functional diversity and regulatory mechanisms within the cell.

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MGRN1 Antibody (LM-1A33) References:

1. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.  |  Lorick, KL., et al. 1999. Proc Natl Acad Sci U S A. 96: 11364-9. PMID: 10500182
2. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.  |  Phan, LK., et al. 2002. J Clin Invest. 110: 1449-59. PMID: 12438443
3. Spongiform degeneration in mahoganoid mutant mice.  |  He, L., et al. 2003. Science. 299: 710-2. PMID: 12560552
4. Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking.  |  Kim, BY., et al. 2007. Mol Biol Cell. 18: 1129-42. PMID: 17229889
5. The ubiquitin-proteasome system in spongiform degenerative disorders.  |  Whatley, BR., et al. 2008. Biochim Biophys Acta. 1782: 700-12. PMID: 18790052
6. The RING finger domain: a recent example of a sequence-structure family.  |  Borden, KL. and Freemont, PS. 1996. Curr Opin Struct Biol. 6: 395-401. PMID: 8804826
7. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.  |  Nagase, T., et al. 1998. DNA Res. 5: 31-9. PMID: 9628581

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MGRN1 Antibody (LM-1A33) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-MGRN1 Antibody (LM-1A33) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MGRN1 Antibody (LM-1A33) Specifications

Alternate Product Name: MGRN1

Product Clone Name: LM-1A33

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 477-577

Epitope Target: MGRN1

Epitope Species: human

Product Reactivity/Detection: MGRN1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for MGRN1 Antibody (LM-1A33): N/A