mGluR-1a/b Antibody (1F7): sc-293437

mGluR-1a/b Antibody (1F7) is a mouse monoclonal IgG2b kappa light chain antibody that detects mGluR-1a/b protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-mGluR-1a/b antibody (1F7) is available as a non-conjugated format. mGluR-1a/b protein, also known as metabotropic glutamate receptor 1, plays a crucial role in the central nervous system by mediating synaptic transmission and plasticity, which are essential for learning and memory processes. mGluR-1a/b is primarily located in the postsynaptic membrane of neurons, where mGluR-1a/b interacts with various intracellular signaling pathways, including the phosphatidylinositol-calcium second messenger system. Proper functioning of mGluR-1a/b is vital for maintaining excitatory neurotransmission and modulating neuronal excitability, making mGluR-1a/b a significant target for research into neurological disorders such as schizophrenia and anxiety. Additionally, mGluR-1a/b can form homodimers, which may influence signaling capabilities and interactions with other proteins, further underscoring mGluR-1a/b′s importance in neurobiology.

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mGluR-1a/b Antibody (1F7) References:

1. Cys-140 is critical for metabotropic glutamate receptor-1 dimerization.  |  Ray, K. and Hauschild, BC. 2000. J Biol Chem. 275: 34245-51. PMID: 10945991
2. Activation of metabotropic glutamate receptor 1 dimers requires glutamate binding in both subunits.  |  Kammermeier, PJ. and Yun, J. 2005. J Pharmacol Exp Ther. 312: 502-8. PMID: 15466247
3. Immunolocalization of metabotropic glutamate receptors 1 and 5 in the synaptic layers of the chicken retina.  |  Sen, M. and Gleason, E. 2006. Vis Neurosci. 23: 221-31. PMID: 16638174
4. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.  |  Hemstapat, K., et al. 2006. Mol Pharmacol. 70: 616-26. PMID: 16645124
5. Ion dependence of ligand binding to metabotropic glutamate receptors.  |  Kuang, D. and Hampson, DR. 2006. Biochem Biophys Res Commun. 345: 1-6. PMID: 16674916
6. mGluR1/5 subtype-specific calcium signalling and induction of long-term potentiation in rat hippocampal oriens/alveus interneurones.  |  Topolnik, L., et al. 2006. J Physiol. 575: 115-31. PMID: 16740609
7. Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells.  |  Kumpost, J., et al. 2008. Neuropharmacology. 55: 409-18. PMID: 18627772
8. The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function.  |  Ohtani, Y., et al. 2014. J Neurosci. 34: 2702-12. PMID: 24523559
9. Metabotropic glutamate receptor 1 splice variants mGluR1a and mGluR1b combine in mGluR1a/b dimers in vivo.  |  Techlovská, Š., et al. 2014. Neuropharmacology. 86: 329-336. PMID: 25158311
10. Optogenetic activation of mGluR1 signaling in the cerebellum induces synaptic plasticity.  |  Surdin, T., et al. 2023. iScience. 26: 105828. PMID: 36632066
11. Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter.  |  Desai, MA., et al. 1995. Mol Pharmacol. 48: 648-57. PMID: 7476890
12. Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants.  |  Stephan, D., et al. 1996. Neuropharmacology. 35: 1649-60. PMID: 9076744

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-mGluR-1a/b Antibody (1F7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-mGluR-1a/b Antibody (1F7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

mGluR-1a/b Antibody (1F7) Specifications

Alternate Product Name: Metabotropic Glutamate Receptor 1

Product Clone Name: 1F7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 387-486

Epitope Target: mGluR-1a/b

Epitope Species: human

Product Reactivity/Detection: mGluR-1a/b

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for mGluR-1a/b Antibody (1F7): N/A