Mex3d Antibody (H-3): sc-514739

Mex3d Antibody (H-3) is a mouse monoclonal IgM antibody that detects Mex3d of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Mex3d antibody (H-3) is available as the non-conjugated form. Mex3d, also known as MEX3, TINO, RKHD1, or RNF193, is a crucial member of the Mex-3 family of RNA-binding phosphoproteins, characterized by two tandemly repeated KH domains and a C-terminal RING finger motif. Mex3d shuttles between the nucleus and cytoplasm via the CRM1-dependent export pathway to regulate post-transcriptional events. Mex3d plays a significant role in maintaining germline totipotency and in the specification of posterior blastomeres during early embryonic development in Caenorhabditis elegans. In humans, four evolutionarily conserved homologs—Mex3a, Mex3b, Mex3c, and Mex3d—highlight this protein family′s importance in various cellular processes. Ubiquitously expressed Mex3d undergoes alternative splicing, resulting in a variant form known as TINO, which has implications for functional diversity. Through specific RNA target interactions, Mex3d regulates gene expression, making Mex3d a valuable target for research in developmental biology and gene regulation.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Mex3d Antibody (H-3) References:

1. Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein.  |  Donnini, M., et al. 2004. J Biol Chem. 279: 20154-66. PMID: 14769789
2. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies.  |  Buchet-Poyau, K., et al. 2007. Nucleic Acids Res. 35: 1289-300. PMID: 17267406
3. MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos.  |  Draper, BW., et al. 1996. Cell. 87: 205-16. PMID: 8861905
4. The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo.  |  Buckanovich, RJ. and Darnell, RB. 1997. Mol Cell Biol. 17: 3194-201. PMID: 9154818

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mex3d Antibody (H-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Mex3d Antibody (H-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mex3d Antibody (H-3) Specifications

Alternate Product Name: Mex3d

Product Clone Name: H-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 475-491

Epitope Target: Mex3d

Epitope Species: human

Product Reactivity/Detection: Mex3d

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Mex3d Antibody (H-3): P: Blocking Peptide, X: TransCruz Reagent