methyl-PP2A-Cα/β Antibody (2A10): sc-81603

methyl-PP2A-Cα/β Antibody (2A10) is a mouse monoclonal IgG1 kappa light chain antibody that detects methyl-PP2A-C alpha/beta in mouse, rat, human, and chicken species by western blotting (WB) and immunoprecipitation (IP). anti-methyl-PP2A-Cα/β antibody (2A10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. methyl-PP2A-C plays a crucial role in cellular signaling pathways by regulating the phosphorylation state of various substrates, which is essential for maintaining cellular homeostasis and controlling processes such as cell division and apoptosis. The reversible carboxymethylation of the C-terminal leucine residue (Leu309) of the PP2A catalytic subunit (PP2A-Cα/β) influences catalytic activity and may be critical for protein phosphatase 2A holoenzyme assembly. This modification affects PP2A interaction with regulatory subunits, modulating function in various signaling pathways. Understanding the dynamics of this post-translational modification helps elucidate complex regulatory mechanisms governing cellular functions and provides insights into potential therapeutic targets for diseases associated with dysregulated phosphatase activity.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-methyl-PP2A-Cα/β Antibody (2A10) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-methyl-PP2A-Cα/β Antibody (2A10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

methyl-PP2A-Cα/β Antibody (2A10) Specifications

Alternate Product Name: PP2AC

Product Clone Name: 2A10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 302-309

Epitope Target: PP2A-C

Epitope Species: human

Product Reactivity/Detection: methylated PP2A-Cα and PP2A-Cβ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: rabbit and porcine

Additional Non-Mammalian Reactivity: chicken, Drosophila, S. cerevisiae

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for methyl-PP2A-Cα/β Antibody (2A10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred p-PP2A-Cα/β antibody is p-PP2A-Cα/β Antibody (F-8): sc-271903.