Molecular structure of Metergoline, CAS Number: 17692-51-2
Metergoline (CAS 17692-51-2)
Alternate Names:
N-Cbz-[(8β)-1,6-Dimethylergolin-8-yl]methylamine
Application:
Metergoline is an antagonist at 5-HT1, 5-HT2, and 5-HT7 serotonin receptors
CAS Number:
17692-51-2
Purity:
≥98%
Molecular Weight:
403.52
Molecular Formula:
C25H29N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Metergoline is an antagonist at 5-HT1, 5-HT2, and SR-7 (5-HT7) serotonin receptors; also SR-1D (5-HT1D) ligand. Metergoline shows moderate affinity for 5-HT6 and high affinity for 5-HT7.
Metergoline (CAS 17692-51-2) References
- Agonist activity of sumatriptan and metergoline at the human 5-HT1D beta receptor: further evidence for a role of the 5-HT1D receptor in the action of sumatriptan. | Miller, KJ., et al. 1992. Eur J Pharmacol. 227: 99-102. PMID: 1330643
- Effects of various serotonin receptor subtype-selective antagonists alone and on m-chlorophenylpiperazine-induced neuroendocrine changes in rats. | Aulakh, CS., et al. 1992. J Pharmacol Exp Ther. 263: 588-95. PMID: 1432690
- Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists. | Bagdy, G., et al. 1992. Eur J Pharmacol. 210: 285-9. PMID: 1535317
- Metergoline blocks the behavioral and neuroendocrine effects of orally administered m-chlorophenylpiperazine in patients with obsessive-compulsive disorder. | Pigott, TA., et al. 1991. Biol Psychiatry. 29: 418-26. PMID: 2018816
- Metergoline-induced cell death in Candida krusei. | Kang, K., et al. 2011. Fungal Biol. 115: 302-9. PMID: 21354537
- Metergoline inhibits the neuronal Nav1.2 voltage-dependent Na(+) channels expressed in Xenopus oocytes. | Lee, JH., et al. 2014. Acta Pharmacol Sin. 35: 862-8. PMID: 24909513
- Molecular basis involved in the blocking effect of antidepressant metergoline on C-type inactivation of Kv1.4 channel. | Bai, HW., et al. 2019. Neuropharmacology. 146: 65-73. PMID: 30465811
- Metergoline Shares Properties with Atypical Antipsychotic Drugs Identified by Gene Expression Signature Screen. | Bortolasci, CC., et al. 2023. Neurotox Res. 41: 502-513. PMID: 37922109
- Effect of metergoline on human anxiety. | Graeff, FG., et al. 1985. Psychopharmacology (Berl). 86: 334-8. PMID: 3929304
- Metergoline in the management of hyperprolactinemic amenorrhea and anovulation. | Falsetti, L., et al. 1982. Gynecol Obstet Invest. 13: 108-16. PMID: 7035305
Inhibitor of:
ASMT, Placental lactogen I, PLP-A, Prolactin, SR-1D, SR-1E, SR-1F, SR-7, and Vmn2r104.Activator of:
SR-1E.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Metergoline, 10 mg | sc-204079 | 10 mg | $80.00 | |||
Metergoline, 50 mg | sc-204079A | 50 mg | $292.00 |