MerTK Antibody (B-4): sc-515338

MerTK Antibody (B-4) is a mouse monoclonal IgG1 antibody that detects MerTK in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MerTK, also known as c-Mer, is a vital member of the Mer/Axl/Tyro3 receptor kinase family, consisting of 984 amino acids and featuring a single tyrosine kinase domain, two Fibronectin type-III domains, and two immunoglobulin-like C2-type domains. MerTK plays essential roles in macrophage activation, platelet aggregation, and apoptotic cell clearance, which maintains tissue homeostasis and prevents inflammation. MerTK functions in the phagocytic process of outer segment ingestion in the retinal pigment epithelium, where MerTK interacts with phosphatidylinositol-specific phospholipase C γ2 (PI-PLC γ2) to facilitate signaling. Disruption of MerTK can lead to impaired phagocytosis in the retinal pigment epithelium, resulting in autosomal recessive retinitis pigmentosa, a condition characterized by retinal photoreceptor cell degeneration. Anti-MerTK antibody (B-4) serves as an invaluable tool for researchers studying these critical pathways and their implications in various diseases.

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MerTK Antibody (B-4) References:

1. Calcified chondroid mesenchymal neoplasms with FN1-receptor tyrosine kinase gene fusions including FGFR2, FGFR1, MERTK, NTRK1, and TEK: a molecular and clinicopathologic analysis.  |  Liu, YJ., et al. 2021. Mod Pathol. 34: 1373-1383. PMID: 33727696
2. N-glycosylation stabilizes MerTK and promotes hepatocellular carcinoma tumor growth.  |  Liu, Y., et al. 2022. Redox Biol. 54: 102366. PMID: 35728303
3. Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa.  |  Mercau, ME., et al. 2023. Sci Adv. 9: eade9459. PMID: 36662852
4. Elevated expression of macrophage MERTK exhibits profibrotic effects and results in defective regulation of efferocytosis function in pulmonary fibrosis.  |  She, Y., et al. 2023. Respir Res. 24: 118. PMID: 37120511
5. Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS.  |  Nguyen, LT., et al. 2023. J Neuroinflammation. 20: 253. PMID: 37926818
6. Big data analytics for MerTK genomics reveals its double-edged sword functions in human diseases.  |  Liu, S., et al. 2024. Redox Biol. 70: 103061. PMID: 38341954
7. Mertk Reduces Blood-Spinal Cord Barrier Permeability Through the Rhoa/Rock1/P-MLC Pathway After Spinal Cord Injury.  |  Lin, J., et al. 2024. Neurosci Bull. 40: 1230-1244. PMID: 38592581
8. Targeted delivery of MerTK protein via cell membrane engineered nanoparticle enhances efferocytosis and attenuates atherosclerosis in diabetic ApoE-/- Mice.  |  Qiu, S., et al. 2024. J Nanobiotechnology. 22: 178. PMID: 38614985
9. Osteopontin regulation of MerTK+ macrophages promotes Crohn's disease intestinal fibrosis.  |  Liu, J., et al. 2024. iScience. 27: 110226. PMID: 39021800
10. Plasma MERTK is causally associated with infection mortality.  |  Drozd, M., et al. 2024. J Infect. 89: 106262. PMID: 39241967

The preferred MerTK antibody is MerTK Antibody (B-1): sc-365499.