MerTK Antibody (A311): sc-53985
- MerTK Antibody (A311) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against the extracellular domain of MerTK of human origin
- recommended for detection of MerTK of human origin by WBIP
- See MerTK (B-1): sc-365499 for MerTK antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MerTK Antibody (A311). This work is in progress.
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MerTK Antibody (A311) is a mouse monoclonal IgG1 antibody that detects MerTK in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). MerTK, also known as c-Mer, is a vital member of the Mer/Axl/Tyro3 receptor kinase family and consists of 984 amino acids, featuring one tyrosine kinase domain, two Fibronectin type-III domains, and two immunoglobulin-like C2-type domains. Anti-MerTK antibody (A311) recognizes a protein crucial for various physiological processes, including macrophage activation, platelet aggregation, and the efficient clearance of apoptotic cells, which is essential for maintaining tissue homeostasis and preventing autoimmune responses. MerTK plays a significant role in the phagocytic process of the retinal pigment epithelium (RPE), where MerTK facilitates the ingestion of outer segments, a function that is critical for retinal health. The signaling mechanism of MerTK involves interaction with phosphatidylinositol-specific phospholipase C γ2 (PI-PLC γ2), which is essential for the proper functioning of the RPE. Mutations in the MerTK gene can disrupt this pathway, leading to conditions such as autosomal recessive retinitis pigmentosa, characterized by the degeneration of retinal photoreceptor cells and subsequent vision loss. MerTK monoclonal antibody (A311) is an invaluable tool for researchers studying these pathways and their implications in retinal diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MerTK Antibody (A311) References:
- Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways. | Chung, WS., et al. 2013. Nature. 504: 394-400. PMID: 24270812
- Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP. | Zhou, Y., et al. 2020. Immunity. 52: 357-373.e9. PMID: 32049051
- MerTK-mediated efferocytosis promotes immune tolerance and tumor progression in osteosarcoma through enhancing M2 polarization and PD-L1 expression. | Lin, J., et al. 2022. Oncoimmunology. 11: 2024941. PMID: 35036076
- Regulation of bone homeostasis by MERTK and TYRO3. | Engelmann, J., et al. 2022. Nat Commun. 13: 7689. PMID: 36509738
- Efferocytosis is restricted by axon guidance molecule EphA4 via ERK/Stat6/MERTK signaling following brain injury. | Soliman, E., et al. 2023. J Neuroinflammation. 20: 256. PMID: 37941008
- Ozone alleviates MSU-induced acute gout pain via upregulating AMPK/GAS6/MerTK/SOCS3 signaling pathway. | Fan, W., et al. 2023. J Transl Med. 21: 890. PMID: 38066599
- Disruption of MerTK increases the efficacy of checkpoint inhibitor by enhancing ferroptosis and immune response in hepatocellular carcinoma. | Wang, S., et al. 2024. Cell Rep Med. 5: 101415. PMID: 38382467
- Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis. | Nerviani, A., et al. 2024. Nat Commun. 15: 2398. PMID: 38493215
- Disturbed flow impairs MerTK-mediated efferocytosis in aortic endothelial cells during atherosclerosis. | Wu, J., et al. 2024. Theranostics. 14: 2427-2441. PMID: 38646649
- MerTK+ macrophages promote melanoma progression and immunotherapy resistance through AhR-ALKAL1 activation. | Wu, N., et al. 2024. Sci Adv. 10: eado8366. PMID: 39365866
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MerTK Antibody (A311) | sc-53985 | 200 µg/ml | $316.00 |