MerTK Antibody (348): sc-53984

MerTK Antibody (348) is a mouse monoclonal IgG1 antibody that detects MerTK in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). MerTK, also known as c-Mer, is a vital member of the Mer/Axl/Tyro3 receptor kinase family and consists of 984 amino acids, featuring one tyrosine kinase domain, two Fibronectin type-III domains, and two immunoglobulin-like C2-type domains. MerTK is crucial for various physiological processes, including macrophage activation, platelet aggregation, and efficient clearance of apoptotic cells, which is essential for maintaining tissue homeostasis and preventing autoimmune responses. Notably, MerTK plays a significant role in the phagocytic process of the retinal pigment epithelium (RPE), where MerTK acts as a signaling molecule that triggers the ingestion of outer segments. The interaction of MerTK with phosphatidylinositol-specific phospholipase C γ2 (PI-PLC γ2) is particularly important, as this interaction facilitates the signaling cascade necessary for effective phagocytosis. Mutations in the MerTK gene can disrupt this pathway, leading to conditions such as autosomal recessive retinitis pigmentosa, which results in the degeneration of retinal photoreceptor cells and subsequent vision loss. With these critical functions and implications in disease, anti-MerTK antibody (348) serves as an invaluable tool for researchers studying cellular processes and potential therapeutic targets in human health.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

MerTK Antibody (348) References:

1. Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis.  |  Morse, C., et al. 2019. Eur Respir J. 54: PMID: 31221805
2. Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators.  |  Pastore, M., et al. 2022. JHEP Rep. 4: 100444. PMID: 35252828
3. Pentoxifylline alleviates ischemic white matter injury through up-regulating Mertk-mediated myelin clearance.  |  Zheng, L., et al. 2022. J Neuroinflammation. 19: 128. PMID: 35642056
4. MERTK activation drives osimertinib resistance in EGFR-mutant non-small cell lung cancer.  |  Yan, D., et al. 2022. J Clin Invest. 132: PMID: 35708914
5. NOX2 inhibition stabilizes vulnerable plaques by enhancing macrophage efferocytosis via MertK/PI3K/AKT pathway.  |  Wang, Y., et al. 2023. Redox Biol. 64: 102763. PMID: 37354827
6. Stress induces behavioral abnormalities by increasing expression of phagocytic receptor MERTK in astrocytes to promote synapse phagocytosis.  |  Byun, YG., et al. 2023. Immunity. 56: 2105-2120.e13. PMID: 37527657
7. Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis.  |  Chakraborty, S., et al. 2023. J Exp Med. 220: PMID: 37615937
8. A+T rich interaction domain protein 3a (Arid3a) impairs Mertk-mediated efferocytosis in cholestasis.  |  Chen, R., et al. 2023. J Hepatol. 79: 1478-1490. PMID: 37659731
9. MerTK is a mediator of alpha-synuclein fibril uptake by human microglia.  |  Dorion, MF., et al. 2024. Brain. 147: 427-443. PMID: 37671615
10. Inhibition of MERTK reduces organ fibrosis in mouse models of fibrotic disease.  |  Pan, Z., et al. 2024. Sci Transl Med. 16: eadj0133. PMID: 38569018

The preferred MerTK antibody is MerTK Antibody (B-1): sc-365499.