Mena Antibody (21): sc-135988

Mena Antibody (21) is a mouse monoclonal IgA kappa light chain antibody that detects Mena protein in mouse, rat, and human samples by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Mena antibody (21) is available as a non-conjugated format. Mena protein plays a crucial role in regulating cytoskeletal dynamics, essential for cellular processes including cell migration, adhesion, and morphology. Mena protein is highly expressed in developing nervous systems, facilitating growth cone motility and axon guidance - processes vital for proper neuronal development and connectivity. Anti-Mena antibody (21) recognizes Mena protein, which interacts with VASP (vasodilator-stimulated phosphoprotein) to contribute to actin polymerization and cytoskeletal organization. Mena protein accumulates at focal adhesions, linking cytoskeleton to extracellular matrix and influencing cellular responses to environmental cues. Understanding Mena protein function and interactions helps elucidate mechanisms underlying various physiological and pathological processes, including those related to Wiskott-Aldrich syndrome, characterized by immune deficiencies and increased susceptibility to lymphoproliferative diseases.

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Mena Antibody (21) References:

1. The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts.  |  Reinhard, M., et al. 1992. EMBO J. 11: 2063-70. PMID: 1318192
2. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization.  |  Symons, M., et al. 1996. Cell. 84: 723-34. PMID: 8625410
3. Defects in Wiskott-Aldrich syndrome blood cells.  |  Remold-O'Donnell, E., et al. 1996. Blood. 87: 2621-31. PMID: 8639877
4. Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42.  |  Kolluri, R., et al. 1996. Proc Natl Acad Sci U S A. 93: 5615-8. PMID: 8643625
5. Studies of the expression of the Wiskott-Aldrich syndrome protein.  |  Stewart, DM., et al. 1996. J Clin Invest. 97: 2627-34. PMID: 8647957
6. Wiskott-Aldrich syndrome: no strict genotype-phenotype correlations but clustering of missense mutations in the amino-terminal part of the WASP gene product.  |  Schindelhauer, D., et al. 1996. Hum Genet. 98: 68-76. PMID: 8682510

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mena Antibody (21) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-Mena Antibody (21) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mena Antibody (21) Specifications

Alternate Product Name: Mena

Product Clone Name: 21

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgA kappa light chain

Amino Acids: 415-541

Epitope Target: Mena

Epitope Species: mouse

Product Reactivity/Detection: Mena

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgA kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for Mena Antibody (21): N/A