Melan-A Antibody (3H2639): sc-71566
- Melan-A Antibody (3H2639) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against recombinant Melan-A of human origin
- recommended for detection of Melan-A of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM
- See Melan-A (A103): sc-20032 for Melan-A antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG1 BP-HRP is the preferred secondary detection reagent for Melan-A Antibody (3H2639) for WB and IHC(P) applications. This reagent is now offered in a bundle with Melan-A Antibody (3H2639) (see ordering information below).
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Melan-A Antibody (3H2639) is a mouse monoclonal IgG1 antibody that detects Melan-A in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Melan-A, also known as MART-1, is a crucial melanocyte differentiation antigen predominantly expressed in melanomas, melanocyte cell lines, and retinal tissues. Melan-A (3H2639) antibody recognizes specific peptides that serve as targets for cytotoxic T lymphocytes, particularly those restricted by HLA-A2, on tumor cell surfaces. This interaction is vital for developing effective cancer immunotherapies, as Melan-A has been shown to elicit strong immune responses in melanoma patients. Anti-Melan-A antibody (3H2639) serves as an essential tool for researchers exploring therapeutic strategies against melanoma and related malignancies, especially given Melan-A′s potential in antigen-specific immunotherapy development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Melan-A Antibody (3H2639) References:
- The melanocytic protein Melan-A/MART-1 has a subcellular localization distinct from typical melanosomal proteins. | De Mazière, AM., et al. 2002. Traffic. 3: 678-93. PMID: 12191019
- Melan-A/MART-1 positive 'pseudonests' in lichenoid inflammatory lesions: an uncommon phenomenon. | Demartini, CS., et al. 2005. Am J Dermatopathol. 27: 370-1. PMID: 16121069
- Melan-A/MART-1-specific CD4 T cells in melanoma patients: identification of new epitopes and ex vivo visualization of specific T cells by MHC class II tetramers. | Bioley, G., et al. 2006. J Immunol. 177: 6769-79. PMID: 17082590
- Comparison of MART-1 frozen sections to permanent sections using a rapid 19-minute protocol. | Cherpelis, BS., et al. 2009. Dermatol Surg. 35: 207-13. PMID: 19215257
- Vaccination of melanoma patients with Melan-A/Mart-1 peptide and Klebsiella outer membrane protein p40 as an adjuvant. | Lienard, D., et al. 2009. J Immunother. 32: 875-83. PMID: 19752746
- Functional T cells targeting NY-ESO-1 or Melan-A are predictive for survival of patients with distant melanoma metastasis. | Weide, B., et al. 2012. J Clin Oncol. 30: 1835-41. PMID: 22529253
- Melan-A/MART-1 immunity in a EWS-ATF1 translocated clear cell sarcoma patient treated with sunitinib: a case report. | Tazzari, M., et al. 2015. BMC Cancer. 15: 58. PMID: 25880253
- Melan-A expression in non-melanocytic carcinoma: A potential diagnostic pitfall. | Zuo, L., et al. 2024. Histol Histopathol. 39: 1037-1041. PMID: 38205829
- Enhancement of cellular immunity in melanoma patients immunized with a peptide from MART-1/Melan A. | Cormier, JN., et al. 1997. Cancer J Sci Am. 3: 37-44. PMID: 9072306
- Cloning and analysis of MART-1/Melan-A human melanoma antigen promoter regions. | Butterfield, LH., et al. 1997. Gene. 191: 129-34. PMID: 9218710
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Melan-A Antibody (3H2639) | sc-71566 | 200 µg/ml | $316.00 | |||
Melan-A Antibody (3H2639): m-IgG1 BP-HRP Bundle | sc-542615 | 200 µg Ab; 20 µg BP | $354.00 |