Meis2 Antibody (63-T): sc-81986

Meis2 Antibody (63-T) is a mouse monoclonal IgG1 kappa light chain antibody that detects Meis2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Meis2 antibody (63-T) is available in a non-conjugated form, allowing for versatile applications in various experimental settings. Meis2, a member of the TALE (three amino acid loop extension) family of homeodomain-containing proteins, plays a crucial role in regulating gene expression during development and adult hematopoietic differentiation. Meis2 (63-T) antibody recognizes a protein essential for forming heteromeric complexes with Hox and Pbx proteins, which enhances DNA binding affinity and specificity. This interaction is vital for proper tissue patterning and cellular differentiation, as Hox proteins, including paralog groups 1-10, are essential for regulating developmental processes. Meis2 expression can be altered in various leukemias, highlighting its significance in both normal physiology and disease states. In the pancreas, Meis2 preferentially associates with Pbx1, forming a complex that interacts with the pancreas-specific homeodomain factor Pdx1, thereby repressing Pdx1-induced transcriptional activation. This regulatory mechanism underscores Meis2′s importance in maintaining proper gene expression patterns in pancreatic development and function.

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Meis2 Antibody (63-T) References:

1. PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins.  |  Shanmugam, K., et al. 1999. Mol Cell Biol. 19: 7577-88. PMID: 10523646
2. Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias.  |  Lawrence, HJ., et al. 1999. Leukemia. 13: 1993-9. PMID: 10602420
3. Expression of the homeodomain transcription factor Meis2 in the embryonic and postnatal retina.  |  Bumsted-O'Brien, KM., et al. 2007. J Comp Neurol. 505: 58-72. PMID: 17729288
4. De novo MEIS2 mutation causes syndromic developmental delay with persistent gastro-esophageal reflux.  |  Fujita, A., et al. 2016. J Hum Genet. 61: 835-8. PMID: 27225850
5. Meis homeobox 2 (MEIS2) inhibits the proliferation and promotes apoptosis of thyroid cancer cell and through the NF-κB signaling pathway.  |  Wen, X., et al. 2021. Bioengineered. 12: 1766-1772. PMID: 33975520
6. Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum.  |  Su, Z., et al. 2022. Development. 149: PMID: 35156680
7. The neuronal transcription factor MEIS2 is a calpain-2 protease target.  |  Müller, T., et al. 2024. J Cell Sci. 137: PMID: 38305737
8. Identification of a new family of Pbx-related homeobox genes.  |  Nakamura, T., et al. 1996. Oncogene. 13: 2235-42. PMID: 8950991
9. AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins.  |  Shen, WF., et al. 1997. Mol Cell Biol. 17: 6448-58. PMID: 9343407
10. Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1.  |  Knoepfler, PS., et al. 1997. Proc Natl Acad Sci U S A. 94: 14553-8. PMID: 9405651
11. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b.  |  Kroon, E., et al. 1998. EMBO J. 17: 3714-25. PMID: 9649441
12. An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2).  |  Swift, GH., et al. 1998. Mol Cell Biol. 18: 5109-20. PMID: 9710595

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Meis2 Antibody (63-T) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-Meis2 Antibody (63-T) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Meis2 Antibody (63-T) Specifications

Alternate Product Name: MEIS2

Product Clone Name: 63-T

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-382

Epitope Target: Meis2

Epitope Species: human

Product Reactivity/Detection: Meis2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for Meis2 Antibody (63-T): N/A

The preferred Meis1/2/3 antibody is Meis1/2/3 Antibody (9.2.7): sc-101850.