Med8 Antibody (A-3): sc-365713
- Med8 Antibody (A-3) is a mouse monoclonal IgM κ provided at 200 µg/ml
- raised against amino acids 1-268 representing full length Med8 of human origin
- recommended for detection of Med8 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Med8 Antibody (A-3) for WB applications. This reagent is now offered in a bundle with Med8 Antibody (A-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Med8 Antibody (A-3) is a mouse monoclonal IgM antibody that detects Med8 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Med8, also known as mediator complex subunit 8 or arc32, is a crucial 268 amino acid protein localized in the nucleus, where Med8 plays a vital role as a component of the mediator complex. This complex serves as a critical bridge between transcriptional activators and RNA polymerase II, facilitating the regulation of Pol II-dependent transcription. The importance of Med8 extends beyond mere transcriptional regulation; Med8 is also involved in the pathway of protein modification and ubiquitination, potentially recruiting E3 ubiquitin-protein ligase complexes to target proteins for proteasomal degradation. The presence of multiple isoforms of Med8, resulting from alternative splicing events, adds another layer of complexity to Med8 function and regulation, making Med8 a significant focus for research in gene expression and cellular signaling pathways. Anti-Med8 antibody (A-3) is an essential tool for researchers aiming to explore the intricate mechanisms of transcriptional regulation and protein interactions in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Med8 Antibody (A-3) | sc-365713 | 200 µg/ml | $316.00 | |||
Med8 Antibody (A-3): m-IgGκ BP-HRP Bundle | sc-535243 | 200 µg Ab; 40 µg BP | $354.00 |