MCP-1 Antibody (ECE.2): sc-52701

MCP-1 Antibody (ECE.2) is a rat monoclonal IgG1 antibody that detects MCP-1 of mouse origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-MCP-1 antibody (ECE.2) is available in a non-conjugated form, specifically designed for researchers seeking to study the role of MCP-1, also known as CCL2, in various biological processes. MCP-1 is a critical chemokine involved in the recruitment of monocytes to sites of inflammation, playing a vital role in the immune response. MCP-1 is primarily produced by activated T lymphocytes and other immune cells in response to pro-inflammatory cytokines such as interleukin-1, tumor necrosis factor-alpha, and interferon-gamma. MCP-1′s ability to attract monocytes is essential for mounting an effective immune response, particularly during infection and tissue injury, where MCP-1 facilitates leukocyte infiltration and promotes healing. Notably, MCP-1 interacts with two distinct receptors, CCR2 and CCR4, which are crucial for mediating MCP-1′s effects on target cells. The differential expression of these receptors in various cell types underscores the complexity of MCP-1′s role in immune regulation and potential as a therapeutic target in inflammatory diseases.

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MCP-1 Antibody (ECE.2) References:

1. MCP-1 expression in endotoxin-induced uveitis.  |  Tuaillon, N., et al. 2002. Invest Ophthalmol Vis Sci. 43: 1493-8. PMID: 11980865
2. Dominant negative MCP-1 blocks human osteoclast differentiation.  |  Morrison, NA., et al. 2014. J Cell Biochem. 115: 303-12. PMID: 23996571
3. MCP-1 promotes invasion and adhesion of human ovarian cancer cells.  |  Furukawa, S., et al. 2013. Anticancer Res. 33: 4785-90. PMID: 24222114
4. Association of MCP-1-2518A/G polymorphism with susceptibility to autoimmune diseases: a meta-analysis.  |  Chen, S., et al. 2016. Clin Rheumatol. 35: 1169-79. PMID: 26318885
5. Autocrine MCP-1/CCR2 signaling stimulates proliferation and migration of renal carcinoma cells.  |  Küper, C., et al. 2016. Oncol Lett. 12: 2201-2209. PMID: 27602164
6. Genetic variants of MCP-1 and CCR2 genes and IgA nephropathy risk.  |  Gao, J., et al. 2016. Oncotarget. 7: 77950-77957. PMID: 27788494
7. Pretreatment Serum MCP-1 Level Predicts Response to Risperidone in Schizophrenia.  |  Lin, Y., et al. 2017. Shanghai Arch Psychiatry. 29: 287-294. PMID: 29276352
8. Detection of serum MCP-1 and TGF-β1 in polymyositis/dermatomyositis patients and its significance.  |  Wu, CY., et al. 2019. Eur J Med Res. 24: 12. PMID: 30764873
9. Protective Effect of the MCP-1 Gene Haplotype against Schizophrenia.  |  Saoud, H., et al. 2019. Biomed Res Int. 2019: 4042615. PMID: 31886209
10. Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis.  |  Queck, A., et al. 2020. Front Immunol. 11: 354. PMID: 32218781

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MCP-1 Antibody (ECE.2) has 31 citations in a variety of scientific publications.

Primary antibodies like Anti-MCP-1 Antibody (ECE.2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MCP-1 Antibody (ECE.2) Specifications

Alternate Product Name: CCL2

Product Clone Name: ECE.2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: MCP-1

Epitope Species: mouse

Product Reactivity/Detection: murine MCP-1

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 31 citations in various scientific publications

Available Conjugates/Forms for MCP-1 Antibody (ECE.2): N/A

The preferred MCP-1 antibody is MCP-1 Antibody (5J): sc-32771.