MCM7 Antibody (G-7): sc-46687
- MCM7 Antibody (G-7) is a mouse monoclonal IgG2a κ, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of MCM7 of human origin
- recommended for detection of MCM7 of mouse, rat and human origin by WB, IP, IF and ELISA
- See MCM7 (141.2): sc-9966 for MCM7 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MCM7 Antibody (G-7) for WB applications. These reagents are now offered in bundles with MCM7 Antibody (G-7) (see ordering information below).
MCM7 Antibody (G-7) is a mouse monoclonal IgG2a antibody that detects MCM7 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MCM7, a member of the mini-chromosome maintenance (MCM) protein family, plays a crucial role in the regulation of DNA replication, ensuring that DNA is replicated only once per cell cycle. This is vital for maintaining genomic stability and preventing over-replication, which can lead to genomic instability and cancer. MCM7, along with other MCM proteins, contains an ATP-binding motif that facilitates the opening of double-stranded DNA in an ATP-dependent manner, a key step in the initiation of DNA replication. MCM7 expression peaks during the transition from the G1 to S phase of the cell cycle and is influenced by E2F transcription factors and various protein kinases. MCM7 interacts with other MCM proteins to form a complex that exhibits DNA helicase activity, essential for unwinding DNA strands during replication. Anti-MCM7 antibody (G-7) serves as an invaluable tool for researchers studying cell cycle regulation, DNA replication mechanisms, and the implications of MCM proteins in cancer biology.
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MCM7 Antibody (G-7) References:
- MCM7 interacts with androgen receptor. | Shi, YK., et al. 2008. Am J Pathol. 173: 1758-67. PMID: 18988800
- MCM7 polymorphisms associated with the AML relapse and overall survival. | Lee, JS., et al. 2017. Ann Hematol. 96: 93-98. PMID: 27837251
- MCM7 promotes cancer progression through cyclin D1-dependent signaling and serves as a prognostic marker for patients with hepatocellular carcinoma. | Qu, K., et al. 2017. Cell Death Dis. 8: e2603. PMID: 28182015
- The Expression of MCM7 is a Useful Biomarker in the Early Diagnostic of Gastric Cancer. | Yang, JY., et al. 2018. Pathol Oncol Res. 24: 367-372. PMID: 28540486
- Pre-RC Protein MCM7 depletion promotes mitotic exit by Inhibiting CDK1 activity. | Zheng, D., et al. 2017. Sci Rep. 7: 2854. PMID: 28588300
- MCM7 silencing promotes cutaneous melanoma cell autophagy and apoptosis by inactivating the AKT1/mTOR signaling pathway. | Yang, Y., et al. 2020. J Cell Biochem. 121: 1283-1294. PMID: 31535400
- miR-107 regulates the effect of MCM7 on the proliferation and apoptosis of colorectal cancer via the PAK2 pathway. | Zhao, M., et al. 2021. Biochem Pharmacol. 190: 114610. PMID: 34010598
- Homozygous mutation in MCM7 causes autosomal recessive primary microcephaly and intellectual disability. | Ravindran, E., et al. 2022. J Med Genet. 59: 453-461. PMID: 34059554
- MCM7 affects the cisplatin resistance of liver cancer cells and the development of liver cancer by regulating the PI3K/Akt signaling pathway. | Su, D. 2022. Immunopharmacol Immunotoxicol. 44: 17-27. PMID: 34821526
- MCM7 supports the stemness of bladder cancer stem-like cells by enhancing autophagic flux. | Mo, L., et al. 2022. iScience. 25: 105029. PMID: 36111256
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MCM7 Antibody (G-7) | sc-46687 | 200 µg/ml | $322.00 | |||
MCM7 Antibody (G-7): m-IgG Fc BP-HRP Bundle | sc-536790 | 200 µg Ab; 10 µg BP | $361.00 | |||
MCM7 Antibody (G-7): m-IgGκ BP-HRP Bundle | sc-533954 | 200 µg Ab; 40 µg BP | $361.00 | |||
MCM7 Antibody (G-7): m-IgG2a BP-HRP Bundle | sc-547873 | 200 µg Ab; 10 µg BP | $361.00 |