MCCA Antibody (D-11): sc-376647

MCCA Antibody (D-11) is a mouse monoclonal IgG2a antibody that detects methylcrotonoyl-CoA carboxylase α chain (MCCA) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MCCA plays a vital role in the metabolism of branched-chain amino acids, specifically in the catabolism of leucine, where MCCA catalyzes the carboxylation of 3-methylcrotonyl-CoA to produce 3-methylglutaconyl-CoA, a crucial step in energy production and metabolic regulation. MCCA is located in the mitochondrial matrix, which highlights the importance of mitochondrial function in cellular metabolism and energy homeostasis. The gene encoding the 725 amino acid MCCA protein is situated on chromosome 3q26-q28 and consists of 19 exons, with mutations leading to 3-methylcrotonylglycinuria, an autosomal recessive disorder that can result in severe metabolic disturbances. Anti-MCCA antibody (D-11) is an essential tool for researchers studying metabolic disorders and mitochondrial function, providing insights into the biochemical pathways that are critical for maintaining cellular health and energy balance.

The preferred MCCA antibody is MCCA Antibody (B-7): sc-365754.