MC4-R Antibody (C-10): sc-55567
- MC4-R Antibody (C-10) is a mouse monoclonal IgG2a κ MC4-R antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 5-60 mapping near the N-terminus of MC4-R of human origin
- MC4-R Antibody (C-10) is recommended for detection of MC4-R of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MC4-R Antibody (C-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for MC4-R Antibody (C-10) for WB applications. These reagents are now offered in bundles with MC4-R Antibody (C-10) (see ordering information below).
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MC4-R Antibody (C-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects MC4-R of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MC4-R (C-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. MC4-R, a member of the melanocortin receptor family, plays a crucial role in regulating energy homeostasis and appetite control, making MC4-R a significant target for research in obesity and metabolic disorders. Located primarily in the central nervous system, particularly in the hypothalamus, MC4-R is involved in signaling pathways that influence feeding behavior and energy expenditure. Proper functioning of MC4-R is essential for maintaining body weight and metabolic balance, and dysregulation of MC4-R has been linked to obesity and related health issues. Understanding MC4-R interactions and signaling mechanisms can provide insights into potential therapeutic targets for weight management and metabolic diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MC4-R Antibody (C-10) References:
- The cloning of a family of genes that encode the melanocortin receptors. | Mountjoy, KG., et al. 1992. Science. 257: 1248-51. PMID: 1325670
- Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA. | Chhajlani, V. and Wikberg, JE. 1992. FEBS Lett. 309: 417-20. PMID: 1516719
- MC4R-dependent suppression of appetite by bone-derived lipocalin 2. | Mosialou, I., et al. 2017. Nature. 543: 385-390. PMID: 28273060
- Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity. | Lotta, LA., et al. 2019. Cell. 177: 597-607.e9. PMID: 31002796
- Effects of melanocortin-4 receptor (MC4R) antagonist on neuropathic pain hypersensitivity in rats - A systematic review and meta-analysis. | Korczeniewska, OA., et al. 2021. Eur J Oral Sci. 129: e12786. PMID: 33786877
- Oestrogen engages brain MC4R signalling to drive physical activity in female mice. | Krause, WC., et al. 2021. Nature. 599: 131-135. PMID: 34646010
- Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. | Mountjoy, KG., et al. 1994. Mol Endocrinol. 8: 1298-308. PMID: 7854347
- Molecular cloning of a mouse melanocortin 5 receptor gene widely expressed in peripheral tissues. | Labbé, O., et al. 1994. Biochemistry. 33: 4543-9. PMID: 8161509
- Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. | Gantz, I., et al. 1993. J Biol Chem. 268: 15174-9. PMID: 8392067
- Molecular cloning of a novel human melanocortin receptor. | Chhajlani, V., et al. 1993. Biochem Biophys Res Commun. 195: 866-73. PMID: 8396929
- Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. | Roselli-Rehfuss, L., et al. 1993. Proc Natl Acad Sci U S A. 90: 8856-60. PMID: 8415620
- Molecular cloning of a novel melanocortin receptor. | Gantz, I., et al. 1993. J Biol Chem. 268: 8246-50. PMID: 8463333
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MC4-R Antibody (C-10) | sc-55567 | 200 µg/ml | $322.00 | |||
MC4-R Antibody (C-10): m-IgG Fc BP-HRP Bundle | sc-525640 | 200 µg Ab; 10 µg BP | $361.00 | |||
MC4-R Antibody (C-10): m-IgG2a BP-HRP Bundle | sc-546347 | 200 µg Ab; 10 µg BP | $361.00 | |||
MC4-R Antibody (C-10) AC | sc-55567 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MC4-R Antibody (C-10) HRP | sc-55567 HRP | 200 µg/ml | $322.00 | |||
MC4-R Antibody (C-10) FITC | sc-55567 FITC | 200 µg/ml | $336.00 | |||
MC4-R Antibody (C-10) PE | sc-55567 PE | 200 µg/ml | $349.00 | |||
MC4-R Antibody (C-10) Alexa Fluor® 488 | sc-55567 AF488 | 200 µg/ml | $364.00 | |||
MC4-R Antibody (C-10) Alexa Fluor® 546 | sc-55567 AF546 | 200 µg/ml | $364.00 | |||
MC4-R Antibody (C-10) Alexa Fluor® 594 | sc-55567 AF594 | 200 µg/ml | $364.00 | |||
MC4-R Antibody (C-10) Alexa Fluor® 647 | sc-55567 AF647 | 200 µg/ml | $364.00 | |||
MC4-R Antibody (C-10) Alexa Fluor® 680 | sc-55567 AF680 | 200 µg/ml | $364.00 | |||
MC4-R Antibody (C-10) Alexa Fluor® 790 | sc-55567 AF790 | 200 µg/ml | $364.00 |