MC4-R Antibody (C-10): sc-55567

MC4-R Antibody (C-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects MC4-R of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MC4-R (C-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. MC4-R, a member of the melanocortin receptor family, plays a crucial role in regulating energy homeostasis and appetite control, making MC4-R a significant target for research in obesity and metabolic disorders. Located primarily in the central nervous system, particularly in the hypothalamus, MC4-R is involved in signaling pathways that influence feeding behavior and energy expenditure. Proper functioning of MC4-R is essential for maintaining body weight and metabolic balance, and dysregulation of MC4-R has been linked to obesity and related health issues. Understanding MC4-R interactions and signaling mechanisms can provide insights into potential therapeutic targets for weight management and metabolic diseases.

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MC4-R Antibody (C-10) References:

1. The cloning of a family of genes that encode the melanocortin receptors.  |  Mountjoy, KG., et al. 1992. Science. 257: 1248-51. PMID: 1325670
2. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA.  |  Chhajlani, V. and Wikberg, JE. 1992. FEBS Lett. 309: 417-20. PMID: 1516719
3. MC4R-dependent suppression of appetite by bone-derived lipocalin 2.  |  Mosialou, I., et al. 2017. Nature. 543: 385-390. PMID: 28273060
4. Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity.  |  Lotta, LA., et al. 2019. Cell. 177: 597-607.e9. PMID: 31002796
5. Effects of melanocortin-4 receptor (MC4R) antagonist on neuropathic pain hypersensitivity in rats - A systematic review and meta-analysis.  |  Korczeniewska, OA., et al. 2021. Eur J Oral Sci. 129: e12786. PMID: 33786877
6. Oestrogen engages brain MC4R signalling to drive physical activity in female mice.  |  Krause, WC., et al. 2021. Nature. 599: 131-135. PMID: 34646010
7. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.  |  Mountjoy, KG., et al. 1994. Mol Endocrinol. 8: 1298-308. PMID: 7854347
8. Molecular cloning of a mouse melanocortin 5 receptor gene widely expressed in peripheral tissues.  |  Labbé, O., et al. 1994. Biochemistry. 33: 4543-9. PMID: 8161509
9. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor.  |  Gantz, I., et al. 1993. J Biol Chem. 268: 15174-9. PMID: 8392067
10. Molecular cloning of a novel human melanocortin receptor.  |  Chhajlani, V., et al. 1993. Biochem Biophys Res Commun. 195: 866-73. PMID: 8396929
11. Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.  |  Roselli-Rehfuss, L., et al. 1993. Proc Natl Acad Sci U S A. 90: 8856-60. PMID: 8415620
12. Molecular cloning of a novel melanocortin receptor.  |  Gantz, I., et al. 1993. J Biol Chem. 268: 8246-50. PMID: 8463333

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MC4-R Antibody (C-10) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-MC4-R Antibody (C-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MC4-R Antibody (C-10) Specifications

Alternate Product Name: MC4-R

Product Clone Name: C-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 5-60

Epitope Target: MC4-R

Epitope Species: human

Product Reactivity/Detection: MC4-R

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for MC4-R Antibody (C-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin