MATH-1 Antibody (H-6): sc-514145
- MATH-1 Antibody (H-6) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 52-77 near the N-terminus of MATH-1 of human origin
- recommended for detection of MATH-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for MATH-1 Antibody (H-6) for WB applications. This reagent is now offered in a bundle with MATH-1 Antibody (H-6) (see ordering information below).
MATH-1 Antibody (H-6) is a mouse monoclonal IgG3 antibody that detects MATH-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MATH-1, also known as Atoh1, Ath1, or HATH-1, is a 351 amino acid helix-loop-helix transcription factor that plays a crucial role in the development of the nervous system. MATH-1 (H-6) antibody helps researchers study neural progenitor cell differentiation, where MATH-1 activates E box-dependent transcription, influencing various neural cell types. MATH-1 expression begins in cranial ganglions and the dorsal part of the central nervous system by embryonic day 9.5 in mice, becomes restricted to the external granular layer of the cerebellum by day 18, and remains undetectable in the adult nervous system. Proper MATH-1 regulation is essential for neural development, as dysregulation can lead to neurodevelopmental disorders. Anti-MATH-1 antibody (H-6) serves as a valuable tool for researchers studying neural differentiation and nervous system development mechanisms.
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MATH-1 Antibody (H-6) References:
- Ectopic expression of the bHLH gene Math1 disturbs neural development. | Isaka, F., et al. 1999. Eur J Neurosci. 11: 2582-8. PMID: 10383648
- Neurotrophins facilitate neuronal differentiation of cultured neural stem cells via induction of mRNA expression of basic helix-loop-helix transcription factors Mash1 and Math1. | Ito, H., et al. 2003. J Neurosci Res. 71: 648-58. PMID: 12584723
- Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway. | Gazit, R., et al. 2004. Development. 131: 903-13. PMID: 14757642
- Dual control of neurogenesis by PC3 through cell cycle inhibition and induction of Math1. | Canzoniere, D., et al. 2004. J Neurosci. 24: 3355-69. PMID: 15056715
- Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis. | Shroyer, NF., et al. 2007. Gastroenterology. 132: 2478-88. PMID: 17570220
- Visualization of intracellular trafficking of Math1 protein in different cell types with a newly-constructed nonviral gene delivery plasmid. | Zhang, W., et al. 2011. J Gene Med. 13: 134-44. PMID: 21308898
- Ectopic hair cell-like cell induction by Math1 mainly involves direct transdifferentiation in neonatal mammalian cochlea. | Yang, J., et al. 2013. Neurosci Lett. 549: 7-11. PMID: 23669638
- Induction of inner ear hair cell-like cells from Math1-transfected mouse ES cells. | Ouji, Y., et al. 2013. Cell Death Dis. 4: e700. PMID: 23828563
- Transcriptional Regulation of Math1 by Aryl Hydrocarbon Receptor: Effect on Math1+ Progenitor Cells in Mouse Small Intestine. | Yagishita, Y., et al. 2023. Mol Cell Biol. 43: 43-63. PMID: 36720468
- S-100 and MATH-1 Protein Expressions Can Be Useful for the Prediction of Clinical Outcome in Neuroblastoma Patients. | Sanlav, G., et al. 2024. J Pediatr Hematol Oncol. 46: 21-28. PMID: 37943051
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MATH-1 Antibody (H-6) | sc-514145 | 200 µg/ml | $316.00 | |||
MATH-1 Antibody (H-6): m-IgG3 BP-HRP Bundle | sc-550517 | 200 µg Ab; 40 µg BP | $354.00 | |||
MATH-1 (H-6) Neutralizing Peptide | sc-514145 P | 100 µg/0.5 ml | $68.00 |