Mast Cell Tryptase Antibody (3H2643): sc-71542

Mast Cell Tryptase Antibody (3H2643) is a mouse monoclonal IgG1 antibody that detects mast cell tryptase in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-mast cell tryptase antibody (3H2643) specifically targets mast cell tryptase, a crucial serine protease that plays a significant role in inflammatory response and tissue remodeling. Mast cell tryptase (3H2643) monoclonal antibody recognizes a protein primarily located in mast cells, which are essential components of the immune system, releasing mediators that influence vascular permeability and recruit other immune cells to sites of inflammation. The presence of mast cell tryptase in tissues can indicate various pathological conditions, including allergic reactions and asthma, making mast cell tryptase a valuable biomarker for understanding mast cell-related diseases. Mast cell tryptase exists as a tetrameric enzyme, stabilized by heparin, which enhances enzymatic activity and allows for effective cleavage of various substrates, further underscoring importance in modulating immune responses. Anti-mast cell tryptase antibody (3H2643) recognizes a protein that interacts with protease-activated receptors, highlighting a role in signaling pathways that regulate inflammation and pain, making mast cell tryptase a critical target for therapeutic interventions.

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Mast Cell Tryptase Antibody (3H2643) References:

1. Mast cell tryptase may modulate endothelial cell phenotype in healing myocardial infarcts.  |  Somasundaram, P., et al. 2005. J Pathol. 205: 102-11. PMID: 15586361
2. Mast cell tryptase causes homologous desensitization of beta-adrenoceptors by Ca2+ sensitization in tracheal smooth muscle.  |  Kobayashi, M., et al. 2008. Clin Exp Allergy. 38: 135-44. PMID: 18028457
3. Mast cell tryptase reduces junctional adhesion molecule-A (JAM-A) expression in intestinal epithelial cells: implications for the mechanisms of barrier dysfunction in irritable bowel syndrome.  |  Wilcz-Villega, EM., et al. 2013. Am J Gastroenterol. 108: 1140-51. PMID: 23588236
4. Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2.  |  Matos, NA., et al. 2013. Inflammation. 36: 1260-7. PMID: 23749157
5. Roles of mast cell tryptase and chymase in airway function.  |  Caughey, GH. 1989. Am J Physiol. 257: L39-46. PMID: 2669522
6. Mast cell tryptase and carboxypeptidase A expression in body fluid and gastrointestinal tract associated with drug-related fatal anaphylaxis.  |  Guo, XJ., et al. 2015. World J Gastroenterol. 21: 13288-93. PMID: 26715811
7. Mast Cell Tryptase Contributes to Pancreatic Cancer Growth through Promoting Angiogenesis via Activation of Angiopoietin-1.  |  Guo, X., et al. 2016. Int J Mol Sci. 17: PMID: 27240355
8. Human serum mast cell tryptase levels in elbow fractures or dislocations and its association with injury severity.  |  Liu, CS., et al. 2020. J Orthop Res. 38: 2015-2019. PMID: 32112583
9. Mast cell tryptase level should be checked in all patients with suspected Kounis syndrome.  |  Khan, S. 2020. Eur Heart J. 41: 3018. PMID: 32705129
10. Histamine, mast cell tryptase and post-exercise hypotension in healthy and collapsed marathon runners.  |  Parsons, IT., et al. 2021. Eur J Appl Physiol. 121: 1451-1459. PMID: 33629149

The preferred Mast Cell Tryptase antibody is Mast Cell Tryptase Antibody (G3): sc-33676.