MARCKSL1 Antibody (K53): sc-130471
- MARCKSL1 Antibody (K53) is a mouse monoclonal IgG2b κ MARCKSL1 antibody, cited in 5 publications, provided at 100 µg/ml
- raised against recombinant MARCKSL1 of human origin
- recommended for detection of MARCKSL1 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MARCKSL1 Antibody (K53). This work is in progress.
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MARCKSL1 Antibody (K53) is a mouse monoclonal IgG2b kappa light chain antibody that detects MARCKSL1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-MARCKSL1 antibody (K53) is available as a non-conjugated format. MARCKSL1, also known as Myristoylated alanine-rich C-kinase substrate-like protein 1, is a 195 amino acid protein that plays a crucial role in cellular signaling and is primarily localized to the plasma membrane. This localization enables MARCKSL1 to interact with various signaling pathways, particularly those involving protein kinase C (PKC), which is essential for regulating processes such as cell adhesion, migration, and secretion. MARCKSL1 is expressed in multiple tissues, with highest levels found in testis and uterus, and participates in regulating integrin activation, thereby influencing integrin-dependent signaling pathways vital for macrophage spreading and immune responses. MARCKSL1′s coordination of membrane-cytoskeletal signaling events underscores its importance in maintaining cellular functions and responses to external stimuli, making MARCKSL1 (K53) monoclonal antibody a valuable tool for researchers studying these critical biological processes.
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MARCKSL1 Antibody (K53) References:
- MARCKS-related protein binds to actin without significantly affecting actin polymerization or network structure. Myristoylated alanine-rich C kinase substrate. | Wohnsland, F., et al. 2000. J Struct Biol. 131: 217-24. PMID: 11052894
- In vivo interaction between dynamitin and MacMARCKS detected by the fluorescent resonance energy transfer method. | Jin, T., et al. 2001. J Biol Chem. 276: 12879-84. PMID: 11278693
- Interaction of the C-terminal region of the rat serotonin transporter with MacMARCKS modulates 5-HT uptake regulation by protein kinase C. | Jess, U., et al. 2002. Biochem Biophys Res Commun. 294: 272-9. PMID: 12051706
- Induction of protein kinase C substrates, Myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP), by amyloid beta-protein in mouse BV-2 microglial cells. | Murphy, A., et al. 2003. Neurosci Lett. 347: 9-12. PMID: 12865129
- The MARCKS family of phospholipid binding proteins: regulation of phospholipase D and other cellular components. | Sundaram, M., et al. 2004. Biochem Cell Biol. 82: 191-200. PMID: 15052337
- Quantitative proteomics analysis of human endothelial cell membrane rafts: evidence of MARCKS and MRP regulation in the sphingosine 1-phosphate-induced barrier enhancement. | Guo, Y., et al. 2007. Mol Cell Proteomics. 6: 689-96. PMID: 17210631
- The regulation of MacMARCKS expression by integrin beta3. | van den Bout, I., et al. 2007. Exp Cell Res. 313: 1260-9. PMID: 17292354
- Investigation into the mechanism regulating MRP localization. | van den Bout, I., et al. 2008. Exp Cell Res. 314: 330-41. PMID: 17897642
- MacMARCKS is not essential for phagocytosis in macrophages. | Underhill, DM., et al. 1998. J Biol Chem. 273: 33619-23. PMID: 9837946
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MARCKSL1 Antibody (K53) | sc-130471 | 100 µg/ml | $333.00 |