MAML2 Antibody (G-07): sc-100778

MAML2 Antibody (G-07) is a mouse monoclonal IgG2a kappa light chain antibody that detects MAML2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-MAML2 antibody (G-07) is available as a non-conjugated format. MAML2, or Mastermind-like protein 2, plays a crucial role as a transcriptional coactivator in the Notch signaling pathway, which is essential for regulating cell fate decisions during development. MAML2 is primarily located in the nucleus, where MAML2 forms complexes with Notch receptors and the DNA-binding protein RBP-Jκ, facilitating the transcription of target genes such as HES1. Proper localization of MAML2 within the nucleus is vital for function, as nuclear presence ensures effective interaction with Notch signaling components to modulate gene expression. Dysregulation of MAML2 has been linked to various cancers, including mucoepidermoid carcinomas and benign Warthin tumors, highlighting MAML2′s importance in both normal development and disease processes.

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MAML2 Antibody (G-07) References:

1. Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.  |  Wu, L., et al. 2002. Mol Cell Biol. 22: 7688-700. PMID: 12370315
2. Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling.  |  Lin, SE., et al. 2002. J Biol Chem. 277: 50612-20. PMID: 12386158
3. Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis.  |  Wu, L. and Griffin, JD. 2004. Semin Cancer Biol. 14: 348-56. PMID: 15288260
4. WNT antagonist, DKK2, is a Notch signaling target in intestinal stem cells: augmentation of a negative regulation system for canonical WNT signaling pathway by the Notch-DKK2 signaling loop in primates.  |  Katoh, M. and Katoh, M. 2007. Int J Mol Med. 19: 197-201. PMID: 17143565
5. Identification of oscillatory genes in somitogenesis from functional genomic analysis of a human mesenchymal stem cell model.  |  William, DA., et al. 2007. Dev Biol. 305: 172-86. PMID: 17362910
6. The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development.  |  Wu, L., et al. 2007. Blood. 110: 3618-23. PMID: 17699740
7. CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: evidence for a common genetic association.  |  Bell, D., et al. 2008. Genes Chromosomes Cancer. 47: 309-14. PMID: 18181164
8. A closer look at Warthin tumors and the t(11;19).  |  Fehr, A., et al. 2008. Cancer Genet Cytogenet. 180: 135-9. PMID: 18206539

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MAML2 Antibody (G-07) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-MAML2 Antibody (G-07) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MAML2 Antibody (G-07) Specifications

Alternate Product Name: MAML2

Product Clone Name: G-07

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 796-895

Epitope Target: MAML2

Epitope Species: human

Product Reactivity/Detection: MAML2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for MAML2 Antibody (G-07): N/A