MAGE-D2 Antibody (FW.6): sc-130443

MAGE-D2 Antibody (FW.6) is a mouse monoclonal IgG1 kappa light chain antibody that detects MAGE-D2 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-MAGE-D2 antibody (FW.6) is available as a non-conjugated monoclonal isotype antibody. The melanoma-associated antigen (MAGE) family, which includes MAGE-D2, is recognized for its role in eliciting immune responses against tumors, making MAGE-D2 a significant target for cancer immunotherapy. MAGE-D2, also known as BCG1, 11B6, HCA10, or JCL-1, is a 606 amino acid protein characterized by the presence of a single MAGE domain. MAGE-D2 is predominantly expressed in the testis and placenta, but expression in various tumors highlights MAGE-D2′s potential role in cancer progression. MAGE-D2 functions as a negative regulator of the p53 tumor suppressor, which is crucial for maintaining genomic stability and preventing tumor formation. MAGE-D2′s interaction with p53 suggests a role in facilitating tumorigenesis and metastasis by inhibiting p53′s protective effects. Multiple isoforms of MAGE-D2 due to alternative splicing events add complexity to MAGE-D2′s functional roles in cancer biology, making MAGE-D2 an important focus for ongoing research and therapeutic development.

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MAGE-D2 Antibody (FW.6) References:

1. A new MAGE gene with ubiquitous expression does not code for known MAGE antigens recognized by T cells.  |  Lucas, S., et al. 1999. Cancer Res. 59: 4100-3. PMID: 10463614
2. Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues.  |  Langnaese, K., et al. 2001. Cytogenet Cell Genet. 94: 233-40. PMID: 11856887
3. Comparative expression analysis of the MAGED genes during embryogenesis and brain development.  |  Bertrand, M., et al. 2004. Dev Dyn. 230: 325-34. PMID: 15162511
4. Identification of a novel MAGE D2 antisense RNA transcript in human tissues.  |  Harper, R., et al. 2004. Biochem Biophys Res Commun. 324: 199-204. PMID: 15465002
5. The role of genetic markers--NAP1L1, MAGE-D2, and MTA1--in defining small-intestinal carcinoid neoplasia.  |  Kidd, M., et al. 2006. Ann Surg Oncol. 13: 253-62. PMID: 16424981
6. MAGED2: a novel p53-dissociator.  |  Papageorgio, C., et al. 2007. Int J Oncol. 31: 1205-11. PMID: 17912449

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MAGE-D2 Antibody (FW.6) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-MAGE-D2 Antibody (FW.6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MAGE-D2 Antibody (FW.6) Specifications

Alternate Product Name: MAGE-D2

Product Clone Name: FW.6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 16-126

Epitope Target: MAGE-D2

Epitope Species: human

Product Reactivity/Detection: MAGE-D2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for MAGE-D2 Antibody (FW.6): N/A