MAdCAM-1 Antibody (G-3): sc-514599

MAdCAM-1 Antibody (G-3) is a mouse monoclonal IgM antibody that detects MAdCAM-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MAdCAM-1, or mucosal addressin cell adhesion molecule 1, plays a crucial role in the immune system by facilitating the homing of lymphocytes to mucosal tissues, particularly in the gut. MAdCAM-1 is primarily located on the endothelial cells of mucosal venules, where MAdCAM-1 interacts with specific leukocyte homing receptors, including L-Selectin and Integrin α4/β7. MAdCAM-1′s ability to direct lymphocyte traffic into Peyer′s patches and the intestinal lamina propria is vital for maintaining mucosal immunity and ensuring an effective immune response to pathogens. Furthermore, MAdCAM-1 is significantly upregulated in inflammatory conditions, such as autoimmune-mediated liver disease, highlighting MAdCAM-1′s importance in the pathogenesis of chronic inflammatory disorders. By utilizing anti-MAdCAM-1 antibody (G-3), researchers can gain insights into the mechanisms of lymphocyte trafficking and the role of this adhesion molecule in various disease states, making anti-MAdCAM-1 antibody (G-3) an invaluable tool for studies in immunology and related fields.

The preferred MAdCAM-1 antibody is MAdCAM-1 Antibody (H-3): sc-365934.