Macrophage Marker Antibody (3F12): sc-53895

Macrophage Marker Antibody (3F12) is a mouse monoclonal IgG2 antibody that detects Macrophage Marker in human samples through immunofluorescence (IF) applications. Anti-Macrophage Marker antibody (3F12) plays a crucial role in identifying macrophages, which are essential components of the immune system, responsible for phagocytosing pathogens and debris. Macrophages are strategically located in tissues throughout the body, where they act as first responders to infection and injury. Macrophages′ ability to recognize and engulf a wide range of pathogens without prior sensitization is vital for initiating and regulating immune responses. Macrophage presence in various tissues not only aids in pathogen clearance but also contributes to tissue homeostasis and repair. Understanding macrophage distribution and function is important for developing therapeutic strategies in diseases characterized by chronic inflammation or impaired immune responses. Macrophage Marker (3F12) antibody serves as a valuable tool for researchers studying the dynamics of the immune system and the role of macrophages in health and disease.

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Macrophage Marker Antibody (3F12) References:

1. Macrophage marker 27E10 on human keratinocytes helps to differentiate discoid lupus erythematosus and Jessner's lymphocytic infiltration of the skin.  |  Kunz, M., et al. 1999. Eur J Dermatol. 9: 107-10. PMID: 10066957
2. Assessment of the macrophage marker quinolinic acid in cerebrospinal fluid after pediatric traumatic brain injury: insight into the timing and severity of injury in child abuse.  |  Berger, RP., et al. 2004. J Neurotrauma. 21: 1123-30. PMID: 15453983
3. A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists.  |  York, MR., et al. 2007. Arthritis Rheum. 56: 1010-20. PMID: 17328080
4. Gr-1 antibody induces STAT signaling, macrophage marker expression and abrogation of myeloid-derived suppressor cell activity in BM cells.  |  Ribechini, E., et al. 2009. Eur J Immunol. 39: 3538-51. PMID: 19830733
5. Macrophage histology in paraffin-embedded multiple sclerosis plaques is demonstrated by the monoclonal pan-macrophage marker HAM-56: correlation with chronicity of the lesion.  |  Adams, CW. and Poston, RN. 1990. Acta Neuropathol. 80: 208-11. PMID: 2143883
6. Stabilin-1/CLEVER-1, a type 2 macrophage marker, is an adhesion and scavenging molecule on human placental macrophages.  |  Palani, S., et al. 2011. Eur J Immunol. 41: 2052-63. PMID: 21480214
7. Measurement of macrophage marker in hyperhaemolytic transfusion reaction: a case report.  |  Win, N., et al. 2012. Transfus Med. 22: 137-41. PMID: 22233101
8. Availability of a microglia and macrophage marker, iba-1, for differential diagnosis of spontaneous malignant reticuloses from astrocytomas in rats.  |  Nakamura, R., et al. 2013. J Toxicol Pathol. 26: 55-60. PMID: 23723569
9. Association of preoperative seizures with reduced expression of soluble CD163, an M2 macrophage marker, in the cerebrospinal fluid in isocitrate dehydrogenase wild-type glioblastoma.  |  Yamanishi, S., et al. 2025. J Neurooncol. 171: 95-103. PMID: 39377994
10. Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins.  |  Holness, CL. and Simmons, DL. 1993. Blood. 81: 1607-13. PMID: 7680921

The preferred Macrophage Marker antibody is Macrophage Marker Antibody (MAC387): sc-66204.