mAChR M2 Antibody (2Q147): sc-71531
- mAChR M2 Antibody (2Q147) is a rat monoclonal IgG2a, cited in 1 publications, provided at 200 µg/ml
- raised against i3 loop of m2 receptor fusion protein
- recommended for detection of mAChR M2 of mouse, rat and human origin by WB, IP and IHC(frozen); not recommended for IF or paraffin-embedded sections
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for mAChR M2 Antibody (2Q147). This work is in progress.
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mAChR M2 Antibody (2Q147) is a rat monoclonal IgG2a antibody that detects muscarinic acetylcholine receptor M2 (mAChR M2) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunohistochemistry on frozen sections. Anti-mAChR M2 antibody (2Q147) plays a crucial role in studying the modulation of various physiological processes, including cardiac function and neurotransmission, by inhibiting adenylate cyclase and regulating ion channel activity. mAChR M2 is primarily located in the heart and central nervous system, where mAChR M2 contributes to the parasympathetic nervous system′s control over heart rate and cognitive functions. The unique distribution of mAChR M2 in these tissues underscores its importance in maintaining homeostasis and responding to cholinergic signaling. The structure of mAChR M2, characterized by seven transmembrane domains typical of G-protein coupled receptors, allows for effective signal transduction upon ligand binding, leading to diverse cellular responses. mAChR M2 (2Q147) antibody is an essential tool for researchers investigating the intricate roles of this receptor in health and disease, providing insights into its function and potential therapeutic targets.
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mAChR M2 Antibody (2Q147) References:
- Distinct internalization of M2 muscarinic acetylcholine receptors confers selective and long-lasting desensitization of signaling to phospholipase C. | Krudewig, R., et al. 2000. J Neurochem. 74: 1721-30. PMID: 10737631
- Agonist mediated internalization of M2 mAChR is beta-arrestin-dependent. | Jones, KT., et al. 2006. J Mol Signal. 1: 7. PMID: 17224084
- m2- and m3-muscarinic acetylcholine receptor mRNAs have different responses to microtubule-affecting drugs. | Fukamauchi, F., et al. 1991. Mol Cell Neurosci. 2: 315-9. PMID: 19912814
- Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats. | Matsumoto, Y., et al. 2010. Urology. 75: 862-7. PMID: 20156651
- Increase in cardiac M2-muscarinic receptor expression is regulated by GATA binding protein 4 (GATA-4) in streptozotocin-induced diabetic rats. | Mar, GY., et al. 2013. Int J Cardiol. 167: 436-41. PMID: 22293779
- Role of M2 and M3 muscarinic acetylcholine receptor subtypes in activation of bladder afferent pathways in spinal cord injured rats. | Matsumoto, Y., et al. 2012. Urology. 79: 1184.e15-20. PMID: 22386753
- M2 muscarinic receptors negatively modulate cell migration in human glioblastoma cells. | Guerriero, C., et al. 2024. Neurochem Int. 174: 105673. PMID: 38185384
- M2 Muscarinic Receptor Stimulation Induces Autophagy in Human Glioblastoma Cancer Stem Cells via mTOR Complex-1 Inhibition. | Guerriero, C., et al. 2023. Cancers (Basel). 16: PMID: 38201453
- Synergistic regulation of m2 muscarinic acetylcholine receptor desensitization and sequestration by G protein-coupled receptor kinase-2 and beta-arrestin-1. | Schlador, ML. and Nathanson, NM. 1997. J Biol Chem. 272: 18882-90. PMID: 9228066
- Internalization of the m2 muscarinic acetylcholine receptor. Arrestin-independent and -dependent pathways. | Pals-Rylaarsdam, R., et al. 1997. J Biol Chem. 272: 23682-9. PMID: 9295310
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
mAChR M2 Antibody (2Q147) | sc-71531 | 200 µg/ml | $322.00 |