MA2 Antibody (B-8): sc-390762

MA2 Antibody (B-8) is a mouse monoclonal IgG3 antibody that detects MA2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MA2 antibody (B-8) is available as the non-conjugated form, which is crucial for research into paraneoplastic neurological disorders (PNDs), rare syndromes linked to underlying neoplasms such as testicular and lung cancers. MA2 protein, also known as onconeuronal antigen MA2, is primarily localized in the nucleolus of normal cells but exhibits a distinct expression pattern in tumor cells, where MA2 protein translocates to the cytoplasm. This change in localization is significant as MA2 (B-8) antibody may play a role in the immune response against onconeural antigens, contributing to the neurological damage observed in PNDs. The MA family of paraneoplastic antigens includes three members: MA1, MA2, and MA3, with MA2 being particularly important due to MA2 protein expression in both brain and testis, highlighting MA2 protein potential as a biomarker for certain cancers. Understanding MA2 protein function and localization can provide insights into the mechanisms of tumorigenesis and the development of targeted therapies.

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MA2 Antibody (B-8) References:

1. Paraneoplastic brain stem encephalitis in a woman with anti-Ma2 antibody.  |  Barnett, M., et al. 2001. J Neurol Neurosurg Psychiatry. 70: 222-5. PMID: 11160472
2. Anti-Ma2 antibody related paraneoplastic limbic/brain stem encephalitis associated with breast cancer expressing Ma1, Ma2, and Ma3 mRNAs.  |  Sahashi, K., et al. 2003. J Neurol Neurosurg Psychiatry. 74: 1332-5. PMID: 12933950
3. Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis.  |  Overeem, S., et al. 2004. Neurology. 62: 138-40. PMID: 14718718
4. Clinical analysis of anti-Ma2-associated encephalitis.  |  Dalmau, J., et al. 2004. Brain. 127: 1831-44. PMID: 15215214
5. Anti-Ma2 associated paraneoplastic neurological syndrome presenting as encephalitis and progressive muscular atrophy.  |  Waragai, M., et al. 2006. J Neurol Neurosurg Psychiatry. 77: 111-3. PMID: 16361608

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MA2 Antibody (B-8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-MA2 Antibody (B-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MA2 Antibody (B-8) Specifications

Alternate Product Name: MA2

Product Clone Name: B-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ lambda light chain

Amino Acids: 121-149

Epitope Target: MA2

Epitope Species: human

Product Reactivity/Detection: MA2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for MA2 Antibody (B-8): P: Blocking Peptide