LYPLA2 Antibody (B-12): sc-390546
- LYPLA2 Antibody (B-12) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 169-187 of LYPLA2 of human origin
- Anti-LYPLA2 Antibody (B-12) is recommended for detection of LYPLA2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-LYPLA2 Antibody (B-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for LYPLA2 Antibody (B-12). This work is in progress.
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LYPLA2 Antibody (B-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects LYPLA2 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LYPLA2 (B-12) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LYPLA2 plays a vital role in lipid metabolism by hydrolyzing lysophospholipids, which are important signaling molecules involved in various cellular processes. These lysophospholipids, which act as detergent-like intermediates in biological membranes, are crucial for maintaining membrane integrity and fluidity. Dysregulation of lysophospholipid levels has been linked to several diseases, including hyperlipidemia and atherosclerosis, highlighting LYPLA2′s importance in health and disease. Both LYPLA1 and LYPLA2, members of the AB hydrolase 2 family, localize to the cytoplasm and exhibit similar enzymatic functions, contributing to lysophospholipid concentration regulation in cellular membranes. Multiple alternatively spliced isoforms of LYPLA2 across various tissues further underscore LYPLA2′s significance in diverse biological contexts, making anti-LYPLA2 antibody (B-12) an essential tool for researchers studying lipid metabolism and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LYPLA2 Antibody (B-12) References:
- A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization. | Wang, A., et al. 1999. Biochim Biophys Acta. 1437: 157-69. PMID: 10064899
- Mammalian lysophospholipases. | Wang, A. and Dennis, EA. 1999. Biochim Biophys Acta. 1439: 1-16. PMID: 10395961
- Subcellular localization and PKC-dependent regulation of the human lysophospholipase A/acyl-protein thioesterase in WISH cells. | Wang, A., et al. 2000. Biochim Biophys Acta. 1484: 207-14. PMID: 10760470
- Annexin II inhibits calcium-dependent phospholipase A1 and lysophospholipase but not triacyl glycerol lipase activities of rat liver hepatic lipase. | Bohn, E., et al. 1992. FEBS Lett. 296: 237-40. PMID: 1531641
- Differential gene expression of blood-derived cell lines in familial combined hyperlipidemia. | Morello, F., et al. 2004. Arterioscler Thromb Vasc Biol. 24: 2149-54. PMID: 15388524
- Lysophospholipase I identified as a ghrelin deacylation enzyme in rat stomach. | Shanado, Y., et al. 2004. Biochem Biophys Res Commun. 325: 1487-94. PMID: 15555596
- Development and biological evaluation of acyl protein thioesterase 1 (APT1) inhibitors. | Deck, P., et al. 2005. Angew Chem Int Ed Engl. 44: 4975-80. PMID: 16003812
- Synthesis and evaluation of acyl protein thioesterase 1 (APT1) inhibitors. | Biel, M., et al. 2006. Chemistry. 12: 4121-43. PMID: 16528788
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LYPLA2 Antibody (B-12) | sc-390546 | 200 µg/ml | $322.00 | |||
LYPLA2 Antibody (B-12) AC | sc-390546 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LYPLA2 Antibody (B-12) HRP | sc-390546 HRP | 200 µg/ml | $322.00 | |||
LYPLA2 Antibody (B-12) FITC | sc-390546 FITC | 200 µg/ml | $336.00 | |||
LYPLA2 Antibody (B-12) PE | sc-390546 PE | 200 µg/ml | $349.00 | |||
LYPLA2 Antibody (B-12) Alexa Fluor® 488 | sc-390546 AF488 | 200 µg/ml | $364.00 | |||
LYPLA2 Antibody (B-12) Alexa Fluor® 546 | sc-390546 AF546 | 200 µg/ml | $364.00 | |||
LYPLA2 Antibody (B-12) Alexa Fluor® 594 | sc-390546 AF594 | 200 µg/ml | $364.00 | |||
LYPLA2 Antibody (B-12) Alexa Fluor® 647 | sc-390546 AF647 | 200 µg/ml | $364.00 | |||
LYPLA2 Antibody (B-12) Alexa Fluor® 680 | sc-390546 AF680 | 200 µg/ml | $364.00 | |||
LYPLA2 Antibody (B-12) Alexa Fluor® 790 | sc-390546 AF790 | 200 µg/ml | $364.00 | |||
LYPLA2 (B-12) Neutralizing Peptide | sc-390546 P | 100 µg/0.5 ml | $69.00 |