LSm2 Antibody (AT2B2): sc-517411

LSm2 Antibody (AT2B2) is a mouse monoclonal IgG2a kappa light chain antibody that detects LSm2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-LSm2 antibody (AT2B2) is available as a non-conjugated format. LSm2 protein plays a crucial role in RNA processing and is a component of the LSm complex, which is essential for the stability and degradation of mRNA. This function helps regulate gene expression and maintain cellular homeostasis, influencing various biological processes such as cell proliferation and differentiation. Dysregulation of LSm2 has been implicated in several diseases, including cancer, where altered RNA metabolism can lead to uncontrolled cell growth. LSm2 protein is located in the nucleus, where LSm2 participates in the assembly of the spliceosomal machinery, further underscoring LSm2′s significance in post-transcriptional regulation. Through interactions with other proteins involved in RNA metabolism, LSm2 serves as a vital player in the intricate network of gene regulation, making anti-LSm2 antibody (AT2B2) an essential tool for researchers studying RNA biology and its implications in health and disease.

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LSm2 Antibody (AT2B2) References:

1. Multiple functional interactions between components of the Lsm2-Lsm8 complex, U6 snRNA, and the yeast La protein.  |  Pannone, BK., et al. 2001. Genetics. 158: 187-96. PMID: 11333229
2. Lsm Proteins are required for normal processing and stability of ribosomal RNAs.  |  Kufel, J., et al. 2003. J Biol Chem. 278: 2147-56. PMID: 12438310
3. The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.  |  Ingelfinger, D., et al. 2002. RNA. 8: 1489-501. PMID: 12515382
4. An Lsm2-Lsm7 complex in Saccharomyces cerevisiae associates with the small nucleolar RNA snR5.  |  Fernandez, CF., et al. 2004. Mol Biol Cell. 15: 2842-52. PMID: 15075370
5. Lsm proteins promote regeneration of pre-mRNA splicing activity.  |  Verdone, L., et al. 2004. Curr Biol. 14: 1487-91. PMID: 15324666
6. Nuclear pre-mRNA decapping and 5' degradation in yeast require the Lsm2-8p complex.  |  Kufel, J., et al. 2004. Mol Cell Biol. 24: 9646-57. PMID: 15485930
7. Reconstitution of two recombinant LSm protein complexes reveals aspects of their architecture, assembly, and function.  |  Zaric, B., et al. 2005. J Biol Chem. 280: 16066-75. PMID: 15711010
8. The Lsm2-8 complex determines nuclear localization of the spliceosomal U6 snRNA.  |  Spiller, MP., et al. 2007. Nucleic Acids Res. 35: 923-9. PMID: 17251193
9. Requirements for nuclear localization of the Lsm2-8p complex and competition between nuclear and cytoplasmic Lsm complexes.  |  Spiller, MP., et al. 2007. J Cell Sci. 120: 4310-20. PMID: 18029398

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LSm2 Antibody (AT2B2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-LSm2 Antibody (AT2B2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LSm2 Antibody (AT2B2) Specifications

Alternate Product Name: LSm2

Product Clone Name: AT2B2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-95

Epitope Target: LSm2

Epitope Species: human

Product Reactivity/Detection: LSm2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide, 1% glycerol, and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for LSm2 Antibody (AT2B2): N/A