Lsh Antibody (C-8): sc-365814
- Lsh Antibody (C-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 259-287 near the N-terminus of Lsh of mouse origin
- recommended for detection of Lsh of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine
- TransCruz reagent for ChIP application (sc-365814 X, 200 µg/0.1 ml)
- See Lsh (H-4): sc-46665 for Lsh antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Lsh Antibody (C-8) for WB applications. These reagents are now offered in bundles with Lsh Antibody (C-8) (see ordering information below).
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Lsh Antibody (C-8) is a mouse monoclonal IgG1 antibody that detects Lymphoid-Specific Helicase (Lsh) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Lsh plays a crucial role in the regulation of transcription by modulating chromatin structure, which is essential for the proper proliferation of peripheral T lymphocytes and the development of lymphoid tissues. Lsh is predominantly expressed in lymphoid precursor cells, as well as in fetal liver and thymus, highlighting its importance during immune system development. Notably, Lsh exhibits significant homology to other SNF2 family members involved in chromatin remodeling, suggesting a function similar to Mi-2, a known transcriptional silencer. This functional similarity indicates that Lsh may be involved in chromatin repression, thereby regulating gene expression rather than facilitating chromatin accessibility. Anti-Lsh antibody (C-8) is an invaluable tool for researchers studying the intricate mechanisms of transcriptional regulation and chromatin dynamics in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Lsh Antibody (C-8) References:
- LSH cooperates with DNA methyltransferases to repress transcription. | Myant, K. and Stancheva, I. 2008. Mol Cell Biol. 28: 215-26. PMID: 17967891
- Senescence delay and repression of p16INK4a by Lsh via recruitment of histone deacetylases in human diploid fibroblasts. | Zhou, R., et al. 2009. Nucleic Acids Res. 37: 5183-96. PMID: 19561196
- Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase. | He, X., et al. 2016. Cancer Res. 76: 5743-5755. PMID: 27302170
- Chromatin remodeling factor LSH affects fumarate hydratase as a cancer driver. | Liu, S. and Tao, YG. 2016. Chin J Cancer. 35: 72. PMID: 27473869
- Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3β-E2F1 Axis Linking Reversely with Survival in Gliomas. | Xiao, D., et al. 2017. Theranostics. 7: 132-143. PMID: 28042322
- GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3-mediated deubiquitination of LSH. | Yang, R., et al. 2019. Oncogene. 38: 7133-7145. PMID: 31417184
- DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism. | Chen, L., et al. 2019. Epigenetics Chromatin. 12: 59. PMID: 31594538
- Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination. | He, Y., et al. 2020. Proc Natl Acad Sci U S A. 117: 20100-20108. PMID: 32727902
- The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation. | Xu, X., et al. 2021. Nat Commun. 12: 3520. PMID: 34112784
- LSH-GAN enables in-silico generation of cells for small sample high dimensional scRNA-seq data. | Lall, S., et al. 2022. Commun Biol. 5: 577. PMID: 35688990
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lsh Antibody (C-8) | sc-365814 | 200 µg/ml | $322.00 | |||
Lsh Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-540371 | 200 µg Ab; 10 µg BP | $361.00 | |||
Lsh Antibody (C-8): m-IgG1 BP-HRP Bundle | sc-542077 | 200 µg Ab; 20 µg BP | $361.00 | |||
Lsh (C-8) Neutralizing Peptide | sc-365814 P | 100 µg/0.5 ml | $69.00 | |||
Lsh Antibody (C-8) X | sc-365814 X | 200 µg/0.1 ml | $322.00 |