Lsc Antibody (G-7): sc-374532

Lsc Antibody (G-7) is a mouse monoclonal IgM antibody that detects Lsc in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Lsc, a member of the Dbl-related protein family, plays a crucial role in regulating the activity of Rho family GTPases, which are essential for various cellular processes, including cytoskeletal dynamics and cell signaling. Lsc′s ability to act as a guanine nucleotide exchange factor (GEF) specifically for Rho GTPases highlights its importance in modulating cellular responses to external stimuli, thereby influencing cell migration, adhesion, and growth. By facilitating the exchange of GDP for GTP, Lsc activates Rho GTPases, which in turn orchestrate the reorganization of the actin cytoskeleton, a process vital for maintaining cell shape and motility. The precise regulation of Rho GTPases by Lsc is critical for normal cellular function, and dysregulation of this pathway can lead to various diseases, including cancer. Anti-Lsc antibody (G-7) provides a valuable tool for researchers aiming to explore the intricate signaling pathways involving Rho GTPases and their implications in health and disease.

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Lsc Antibody (G-7) References:

1. Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF.  |  Taya, S., et al. 2001. J Cell Biol. 155: 809-20. PMID: 11724822
2. Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA.  |  Booden, MA., et al. 2002. Mol Cell Biol. 22: 4053-61. PMID: 12024019
3. Characterization of leukemia-associated Rho guanine nucleotide exchange factor (LARG) expression during murine development.  |  Becknell, B., et al. 2003. Cell Tissue Res. 314: 361-6. PMID: 14513355
4. Angiotensin II up-regulates the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF), a regulator of G protein signaling domain-containing RhoGEF, in vascular smooth muscle cells.  |  Ying, Z., et al. 2006. Mol Pharmacol. 69: 932-40. PMID: 16354763
5. Influence of simulated microgravity on the activation of the small GTPase Rho involved in cytoskeletal formation--molecular cloning and sequencing of bovine leukemia-associated guanine nucleotide exchange factor.  |  Higashibata, A., et al. 2006. BMC Biochem. 7: 19. PMID: 16803636
6. Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia-associated rho Guanine-nucleotide exchange factor.  |  Grabocka, E. and Wedegaertner, PB. 2007. Mol Pharmacol. 72: 993-1002. PMID: 17609419
7. Differential baseline expression and angiotensin II-stimulation of leukemia-associated RhoGEF in vascular smooth muscle cells of spontaneously hypertensive rats.  |  Chiu, WC., et al. 2012. Int J Nanomedicine. 7: 5929-39. PMID: 23233801
8. Leukemia-associated Rho guanine-nucleotide exchange factor is not critical for RhoA regulation, yet is important for platelet activation and thrombosis in mice.  |  Williams, CM., et al. 2015. J Thromb Haemost. 13: 2102-7. PMID: 26334261
9. Ligand-dependent serum response factor activation by the human CC chemokine receptors CCR2a and CCR2b is mediated by G proteins of the Gq family.  |  Vatter, P., et al. 2016. J Leukoc Biol. 99: 979-91. PMID: 26823487
10. Small chemical compounds Y16 and Rhosin can inhibit calcium sensitization pathway in vascular smooth muscle cells of spontaneously hypertensive rats.  |  Chiu, WC., et al. 2021. J Formos Med Assoc. 120: 1863-1868. PMID: 33893012

The preferred RhoGEF p115 antibody is RhoGEF p115 Antibody (C-9): sc-74565.