LRRC58 Antibody (C-4): sc-515597

LRRC58 Antibody (C-4) is a mouse monoclonal IgM antibody that detects LRRC58 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-LRRC58 antibody (C-4) is available as the non-conjugated form. LRRC58, also known as leucine-rich repeat-containing protein 58, is composed of 371 amino acids and features nine leucine-rich repeats, which are critical for protein-protein interactions and play a significant role in various cellular processes. LRRC58 is primarily located in the cytoplasm, where LRRC58 is involved in the regulation of signaling pathways essential for cellular communication and function. Proper localization of LRRC58 ensures effective interaction with binding partners and participation in the modulation of cellular responses. LRRC58 is encoded on human chromosome 3q13.33, a region known for involvement in multiple human cancers, including nasopharyngeal carcinoma, due to the presence of tumor suppressor gene clusters. The unique structural features of LRRC58, along with specific cellular localization, underscore LRRC58′s importance in maintaining cellular homeostasis and potential role in oncogenesis, making LRRC58 a valuable target for research in cancer biology and therapeutic development.

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LRRC58 Antibody (C-4) References:

1. The molecular genetics of Marfan syndrome and related microfibrillopathies.  |  Robinson, PN. and Godfrey, M. 2000. J Med Genet. 37: 9-25. PMID: 10633129
2. Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome.  |  Maho, A., et al. 1999. Cytogenet Cell Genet. 87: 265-8. PMID: 10702689
3. [New tumor suppressor genes in hot spots of human chromosome 3: new methods of identification].  |  Braga, EA., et al. 2003. Mol Biol (Mosk). 37: 194-211. PMID: 12723467
4. Plasticity of human chromosome 3 during primate evolution.  |  Tsend-Ayush, E., et al. 2004. Genomics. 83: 193-202. PMID: 14706448
5. Comparative cytogenetics of human chromosome 3q21.3 reveals a hot spot for ectopic recombination in hominoid evolution.  |  Yue, Y., et al. 2005. Genomics. 85: 36-47. PMID: 15607420
6. Methylation of the tumor suppressor gene RASSF1A in human tumors.  |  Pfeifer, GP. and Dammann, R. 2005. Biochemistry (Mosc). 70: 576-83. PMID: 15948711
7. High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene.  |  Nair, PN., et al. 2007. Cancer Genet Cytogenet. 174: 100-10. PMID: 17452250
8. A second locus for Marfan syndrome maps to chromosome 3p24.2-p25.  |  Collod, G., et al. 1994. Nat Genet. 8: 264-8. PMID: 7632217
9. Mutilating neuropathic ulcerations in a chromosome 3q13-q22 linked Charcot-Marie-Tooth disease type 2B family.  |  De Jonghe, P., et al. 1997. J Neurol Neurosurg Psychiatry. 62: 570-3. PMID: 9219740

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LRRC58 Antibody (C-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-LRRC58 Antibody (C-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LRRC58 Antibody (C-4) Specifications

Alternate Product Name: LRRC58

Product Clone Name: C-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 263-287

Epitope Target: LRRC58

Epitope Species: human

Product Reactivity/Detection: LRRC58

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for LRRC58 Antibody (C-4): P: Blocking Peptide