LRRC4 Antibody (C-11): sc-376475
- LRRC4 Antibody (C-11) is a mouse monoclonal IgG1 κ LRRC4 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 458-525 mapping within an internal region of LRRC4 of human origin
- LRRC4 Antibody (C-11) is recommended for detection of LRRC4 of human origin by WB, IP, IF and ELISA
- Anti-LRRC4 Antibody (C-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for LRRC4 Antibody (C-11). This work is in progress.
LRRC4 Antibody (C-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects LRRC4 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LRRC4 (C-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The leucine-rich repeat-containing protein 4 (LRRC4), also known as Brain tumor-associated protein BAG, Nasopharyngeal carcinoma-associated gene 14 protein (NAG14), or Netrin-G2 ligand (NGL-2), plays a crucial role in the central nervous system, where LRRC4 is specifically expressed in the brain. One of the key aspects of LRRC4 is a structure that includes one immunoglobulin-like domain and nine leucine-rich repeats. These motifs form a hydrophobic α/β horseshoe fold, allowing for the accommodation of several leucine residues within a tightly packed core. The structural integrity provided by these leucine-rich repeats is essential for mediating protein-protein interactions, which are vital for various cellular processes, including signaling pathways and synaptic functions. Notably, methylation of the LRRC4 gene is frequently observed in gliomas, highlighting LRRC4′s potential as a biomarker for diagnosis and a promising therapeutic target.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LRRC4 Antibody (C-11) References:
- The leucine-rich repeat as a protein recognition motif. | Kobe, B. and Kajava, AV. 2001. Curr Opin Struct Biol. 11: 725-32. PMID: 11751054
- Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily. | Zhang, Q., et al. 2005. FEBS Lett. 579: 3674-82. PMID: 15967442
- Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases. | Matsushima, N., et al. 2005. Cell Mol Life Sci. 62: 2771-91. PMID: 16231091
- LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit proliferation of glioma cells in vitro by modulating the extracellular signal-regulated kinase/protein kinase B/nuclear factor-kappaB pathway. | Wu, M., et al. 2006. Mol Biol Cell. 17: 3534-42. PMID: 16723503
- [Inhibitory effect of LRRC4 on the mobility and invasion of glioblastomas through the SDF-1alpha/CXCR4 axis]. | Chen, Q., et al. 2007. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 32: 735-41. PMID: 18007062
- Promoter hypermethylation-mediated inactivation of LRRC4 in gliomas. | Zhang, Z., et al. 2008. BMC Mol Biol. 9: 99. PMID: 18976507
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LRRC4 Antibody (C-11) | sc-376475 | 200 µg/ml | $322.00 | |||
LRRC4 Antibody (C-11) AC | sc-376475 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LRRC4 Antibody (C-11) HRP | sc-376475 HRP | 200 µg/ml | $322.00 | |||
LRRC4 Antibody (C-11) FITC | sc-376475 FITC | 200 µg/ml | $336.00 | |||
LRRC4 Antibody (C-11) PE | sc-376475 PE | 200 µg/ml | $349.00 | |||
LRRC4 Antibody (C-11) Alexa Fluor® 488 | sc-376475 AF488 | 200 µg/ml | $364.00 | |||
LRRC4 Antibody (C-11) Alexa Fluor® 546 | sc-376475 AF546 | 200 µg/ml | $364.00 | |||
LRRC4 Antibody (C-11) Alexa Fluor® 594 | sc-376475 AF594 | 200 µg/ml | $364.00 | |||
LRRC4 Antibody (C-11) Alexa Fluor® 647 | sc-376475 AF647 | 200 µg/ml | $364.00 | |||
LRRC4 Antibody (C-11) Alexa Fluor® 680 | sc-376475 AF680 | 200 µg/ml | $364.00 | |||
LRRC4 Antibody (C-11) Alexa Fluor® 790 | sc-376475 AF790 | 200 µg/ml | $364.00 |